Glucagonoma, a rare
neuroendocrine tumor of the pancreas, which is often misdiagnosed because of non-characteristic clinical manifestations. In addition, the treatment has not been well established for this disease so far. We here report a case of
glucagonoma previous misdiagnosed as recurrent
erythema. In this case,
necrolytic migratory erythema was the main clinical manifestation, and he received surgical resection after admission although with liver
metastasis. Postoperative pathological results showed that the heterogeneity of proliferative index in primary (Ki-67: 5~10%) and metastatic (Ki-67: 25~30%)
tumors were obviously observed. One month postoperatively, abdominal CT and MRI showed multiple liver
metastasis (type III) again. Interestingly, the
skin rash was obviously improved
after treatment with
somatostatin combined with
chemotherapy (
octreotide,
temozolomide and
capecitabine). Subsequently, the patient received transarterial embolization (TAE). Up to now, no progression was noted for liver
metastasis. Due to its rarity, clinical diagnosis is challenging; thus, further understanding of the disease by clinicians is helpful for early diagnosis and treatment, so as to improve the prognosis of patients.