Hypoxia: a barricade to conquer the pancreatic cancer.

Abstract

Pancreatic cancer (PC) remains one of the most extremely lethal malignancies worldwide due to late diagnosis and early metastasis, with a 1-year overall survival rate of approximately 20%. The hypoxic microenvironment, induced by intratumoral hypoxia, promotes tumor invasion and progression, leading to chemotherapy or radiotherapy resistance and eventual mortality after treatment of PC. However, the role of the hypoxic microenvironment in PC is complicated and requires further investigation. In this article, we review recent advances regarding the regulation of malignant behaviors in PC, which provide insight into the potential of hypoxic microenvironment activation therapy for the therapeutic agents.

• Authors: Zhen Tan, Jin Xu, Bo Zhang, Si Shi, Xianjun Yu, Chen Liang
• Journal: Cellular and molecular life sciences : CMLS (Cell Mol Life Sci) Vol. 77 Issue 16 Pg. 3077-3083 (Aug 2020) ISSN: 1420-9071 [Electronic] Switzerland
• PMID: 31907561 (Publication Type: Journal Article, Review)

Chemical References

• Antineoplastic Agents

Topics

• Antineoplastic Agents (therapeutic use)
• Cell Hypoxia (drug effects, physiology)
• Disease Progression
• Humans
• Pancreatic Neoplasms (drug therapy, pathology)
• Tumor Microenvironment (physiology)