Loss of MTUS1 Expression Is Associated With Poor Prognosis in Patients With Gallbladder Carcinoma.

Abstract

BACKGROUND/AIM:

Microtubule-associated scaffold protein 1 (MTUS1) acts as tumor suppressor in several cancer types. This study assessed the relationship between clinicopathological characteristics and expression of microRNA candidates based on MTUS1 expression in gallbladder cancer (GBC).

MATERIALS AND METHODS:

MTUS1 expression was evaluated by immunohistochemical staining of tissue microarrays from 109 cases of GBC. The association of MTUS1 expression with clinicopathological factors was explored. Two microRNA candidates (miR-19a-3p, and miR-19b-3p), which were identified by a literature review and computational analysis, were assessed in GBC tissue samples by quantitative real-time polymerase chain reaction.

RESULTS:

Low MTUS1 expression in GBC was associated with high histological grade, perineural invasion, lymphovascular invasion, high T-stage, advanced TNM stage, poorer disease-free survival, and poorer cancer-specific survival. No statistical association between MTUS1 expression and expression of microRNA candidates was observed.

CONCLUSION:

MTUS1 may act as tumor suppressor and might be a potential biomarker for predicting prognosis in GBC.

• Authors: Jongmin Sim, Yeseul Kim, Hyungsung Kim, Seongsik Bang, Seungyun Jee, Seongun Park, Su-Jin Shin, Kiseok Jang
• Journal: In vivo (Athens, Greece) (In Vivo) 2020 Jan-Feb Vol. 34 Issue 1 Pg. 125-132 ISSN: 1791-7549 [Electronic] Greece
• PMID: 31882471 (Publication Type: Journal Article)
• Copyright: Copyright© 2020, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.

Chemical References

• Biomarkers, Tumor
• MTUS1 protein, human
• MicroRNAs
• Tumor Suppressor Proteins

Topics

• Biomarkers, Tumor (genetics)
• Disease-Free Survival
• Female
• Gallbladder Neoplasms (genetics, pathology)
• Gene Expression Regulation, Neoplastic (genetics)
• Humans
• Male
• MicroRNAs (genetics)
• Middle Aged
• Neoplasm Staging (methods)
• Prognosis
• Tumor Suppressor Proteins (genetics)