Abstract | INTRODUCTION: conjunctival melanomas have high local relapse rates. Oncologic and visual outcomes can be improved with proton therapy and no-touch surgery. MATERIAL AND METHODS: a monocentric retrospective study of consecutive patients treated with surgery and proton therapy for conjunctival melanoma was conducted. Proton therapy was performed to a total dose of 45 Grays physical dose delivered in eight fractions over two weeks. RESULTS: Ninety-two patients were included. The mean age was 63-year-old. 65.2% of patients had primary acquired melanosis. The mean tumor thickness and diameter was 2.5 mm and 7.0 mm respectively. The clinical stage was T1 in 71.6% of cases, with a quadrangular involvement of more than 90° in 69% of cases. Conjunctival melanomas were of epithelioid cell-type in 40% of cases. Mean follow-up was 4.7 years. Five-year local failure rate was 33.2%. Of 25 local recurrences, 14 were marginal/out-of-field, 4 in-field, others were undetermined. First surgery at expert center resulted in 24.3% of local failure at 5 years versus 38.7% if performed elsewhere (p = 0.41). Salvage exenteration was performed in 13 patients. Tumor stage and quadrangular involvement were significant factors for local failure. Five-year progression-free survival and cause-specific death rates were 61.5 and 3.6%. Stage and epithelioid type were associated with poorer progression-free survival. Trophic toxicity occurred in 22.9% of patients and was treated locally, with grafts in 7 patients. Glaucoma and cataract occurred in 13 and 22 patients respectively. Prognostic factors for visual deterioration were age, tumor extent (multifocality, quadrangular involvement > 180°) and cryotherapy. CONCLUSIONS: 5-year local failure rate after postoperative proton therapy for conjunctival melanoma was of 33.2%. Radiation-induced complications were overall manageable.
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Authors | Juliette Thariat, Julia Salleron, Celia Maschi, Edouard Fevrier, Sandra Lassalle, Lauris Gastaud, Stephanie Baillif, Audrey Claren, Florent Baumard, Joel Herault, Jean Pierre Caujolle |
Journal | Radiation oncology (London, England)
(Radiat Oncol)
Vol. 14
Issue 1
Pg. 239
(Dec 27 2019)
ISSN: 1748-717X [Electronic] England |
PMID | 31881977
(Publication Type: Journal Article)
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Topics |
- Aged
- Conjunctival Neoplasms
(mortality, pathology, radiotherapy)
- Female
- Humans
- Male
- Melanoma
(mortality, pathology, radiotherapy)
- Middle Aged
- Neoplasm Recurrence, Local
(mortality, pathology, radiotherapy)
- Postoperative Care
- Prognosis
- Proton Therapy
(mortality)
- Retrospective Studies
- Survival Rate
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