Objective:
Preeclampsia is a common disorder of pregnancy, causing significant morbidity and mortality for mothers and infants. Several molecules, including
glycosylated fibronectin (GlyFn), the
inhibin-related
proteins, anti-müllerian
hormone (AMH), and the
insulin-like growth factor axis, are altered in maternal plasma in the setting of
preeclampsia; however, these molecules have not been previously measured in cord blood of infants born to mothers with
preeclampsia, which may represent changes in fetal physiology. We evaluated potential
biomarkers of
preeclampsia in umbilical cord blood to fill the gap in knowledge. Methods: This is a case-control study of 196 neonates born at a tertiary teaching hospital in Boston from 2010-2017. Forty-nine neonates born to mothers with
preeclampsia were matched 1:3 by gestational age, sex, and
birth weight z-score with 147 controls. Eleven analytes were measured in cord blood by
enzyme-linked
immunosorbent assay. Binary logistic regression analyses were performed to evaluate associations between
preeclampsia and analytes. Results: Mean cord blood levels of GlyFn and total
inhibin were significantly lower in neonates born to mothers with
preeclampsia compared to controls, and AMH levels were significantly higher in males born to mothers with
preeclampsia than male controls. Associations remained significant after controlling for maternal and neonatal characteristics. Conclusion: Cord blood levels of GlyFn and
inhibin are decreased and AMH (male) levels are increased in infants of preeclamptic mothers, which is opposite the pattern these
biomarkers show in serum of mothers with
preeclampsia. These molecules may be important in the pathophysiology and long-term effects of
preeclampsia on the developing fetus. Abbreviations: AMH = anti-müllerian
hormone; ELISA =
enzyme-linked
immunosorbent assay; GlyFn =
glycosylated fibronectin; IGF =
insulin-like growth factor; IGFBP5 =
insulin-like growth factor binding protein 5; LOD = limit of detection;
PAPP-A =
pregnancy-associated plasma protein A; PAPP-A2 = pregnancy-associated
plasma protein A2.