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Role Reversal: A Pro-metastatic Function of E-Cadherin.

Abstract
Carcinoma cells often acquire mobility and invasiveness by undergoing epithelial-to-mesenchymal transition, and yet most metastatic lesions remain epithelial in nature. Recently, in Nature, Padmanaban et al. (2019) demonstrated that the quintessential epithelial marker E-cadherin promotes metastasis of invasive ductal breast carcinoma by enhancing the survival of tumor cells.
AuthorsMinhong Shen, Yibin Kang
JournalDevelopmental cell (Dev Cell) Vol. 51 Issue 4 Pg. 417-419 (11 18 2019) ISSN: 1878-1551 [Electronic] United States
PMID31743661 (Publication Type: Journal Article, Comment)
CopyrightCopyright © 2019. Published by Elsevier Inc.
Chemical References
  • Cadherins
Topics
  • Breast Neoplasms
  • Cadherins
  • Cell Line, Tumor
  • Epithelial-Mesenchymal Transition
  • Humans

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