Abstract | BACKGROUND AND PURPOSE: Disordered lipid metabolism and disturbed mitochondrial bioenergetics play pivotal roles in the initiation and development of diabetic kidney disease (DKD). Berberine is a plant alkaloid, used in Chinese herbal medicine. It has multiple therapeutic actions on diabetes mellitus and its complications, including regulation of glucose and lipid metabolism, improvement of insulin sensitivity, and alleviation of oxidative damage. Here, we investigated the reno-protective effects of berberine. EXPERIMENTAL APPROACH: We used samples from DKD patients and experiments with models of DKD (db/db mice) and cultured podocytes, to characterize energy metabolism profiles using metabolomics. Molecular targets and mechanisms involved in the regulation of mitochondrial function and bioenergetics by berberine were investigated, along with its effects on metabolic alterations in DKD mice. KEY RESULTS: CONCLUSION AND IMPLICATIONS: PGC-1α-mediated mitochondrial bioenergetics could play a key role in lipid disorder-induced podocyte damage and development of DKD in mice. Restoration of PGC-1α activity and the energy homeostasis by berberine might be a potential therapeutic strategy against DKD.
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Authors | Xin Qin, Ming Jiang, Yan Zhao, Jing Gong, Hao Su, Fen Yuan, Ke Fang, Xiaoyi Yuan, Xiao Yu, Hui Dong, Fuer Lu |
Journal | British journal of pharmacology
(Br J Pharmacol)
Vol. 177
Issue 16
Pg. 3646-3661
(08 2020)
ISSN: 1476-5381 [Electronic] England |
PMID | 31734944
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Copyright | © 2019 The Authors. British Journal of Pharmacology published by John Wiley & Sons Ltd on behalf of British Pharmacological Society. |
Chemical References |
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
- Berberine
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Topics |
- Animals
- Berberine
(pharmacology)
- Diabetes Mellitus
(metabolism)
- Diabetic Nephropathies
(drug therapy, metabolism, prevention & control)
- Homeostasis
- Humans
- Mice
- Mitochondria
(metabolism)
- Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha
(metabolism)
- Podocytes
(metabolism)
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