LncRNA SNHG7 is an Oncogenic Biomarker Interacting with MicroRNA-193b in Colon Carcinogenesis.

Abstract

BACKGROUND:

The expression and significance of small nucleolar RNA host gene 7 (SNHG7) in early-stage colon carcinogenesis remains unclear.

METHODS:

The level of SNHG7 and microRNA-193b (miR-193b) was detected by qRT-PCR in colon tumor tissues and cells. The interaction of SNHG7 and miR-193b and the influence of SNHG7 silencing on colon tumor cells was evaluated.

RESULTS:

Stepwise upregulated SNHG7 in colon advanced adenomas and early-stage cancer negatively correlates with miR-193b level, the direct interaction was confirmed in vitro. SNHG7 silencing in HT29 cells decreased proliferation and promoted apoptosis by inhibiting K-ras/ERK/cyclinD1.

CONCLUSIONS:

SNHG7 is an oncogenic biomarker in colon carcinogenesis. The effect may be mediated by interaction with miR-193b.

• Authors: K L Liu, J Wu, W K Li, N S Li, Q Li, Y Q Lao
• Journal: Clinical laboratory (Clin Lab) Vol. 65 Issue 11 (Nov 01 2019) ISSN: 1433-6510 [Print] Germany
• PMID: 31721543 (Publication Type: Journal Article)

Chemical References

• 3' Untranslated Regions
• Biomarkers, Tumor
• MIRN193 microRNA, human
• MicroRNAs
• RNA, Long Noncoding
• long noncoding RNA SNHG8, human

Topics

• 3' Untranslated Regions (genetics)
• Adenoma (genetics, metabolism, pathology)
• Apoptosis (genetics)
• Base Sequence
• Biomarkers, Tumor (genetics)
• Carcinogenesis (genetics, metabolism)
• Cell Proliferation (genetics)
• Colon (metabolism, pathology)
• Colonic Neoplasms (genetics, metabolism, pathology)
• Gene Expression Regulation, Neoplastic
• HEK293 Cells
• HT29 Cells
• Humans
• MicroRNAs (genetics)
• RNA Interference
• RNA, Long Noncoding (genetics, metabolism)
• Sequence Homology, Nucleic Acid