Small Nucleolar RNA (snoRNA)

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24 relevant articles (0 outcomes, 2 trials/studies) found for this Bio-Agent

Description: Small nuclear RNAs that are involved in the processing of pre-ribosomal RNA in the nucleolus. Box C/D containing snoRNAs (U14, U15, U16, U20, U21 and U24-U63) direct site-specific methylation of various ribose moieties. Box H/ACA containing snoRNAs (E2, E3, U19, U23, and U64-U72) direct the conversion of specific uridines to pseudouridine. Site-specific cleavages resulting in the mature ribosomal RNAs are directed by snoRNAs U3, U8, U14, U22 and the snoRNA components of RNase MRP and RNase P.

Also Known As:

snoRNA; RNA, Small Nucleolar

Bio-Agent Context: Research Results

Nucleic Acids, Nucleotides, and Nucleosides: 1

Nucleic Acids: 1427

RNA: 23448

Nuclear RNA: 179

Small Nuclear RNA: 59

Small Nucleolar RNA: 24

U3 small nucleolar RNA: 4

growth arrest specific transcript 5: 1

Untranslated RNA: 56

Small Nuclear RNA: 59

Small Nucleolar RNA: 24

U3 small nucleolar RNA: 4

growth arrest specific transcript 5: 1

Experts

1.	Ding, Feng: 2 articles (01/2008 - 06/2005)
2.	Francke, Uta: 2 articles (01/2008 - 06/2005)
3.	Kibel, Adam S: 1 article (04/2008)
4.	Calle, Eugenia E: 1 article (04/2008)
5.	Guo, Peng: 1 article (04/2008)
6.	Zhou, Wei: 1 article (04/2008)
7.	Dong, Xue-Yuan: 1 article (04/2008)
8.	Talbot, Jeffrey T: 1 article (04/2008)
9.	Petros, John: 1 article (04/2008)
10.	Dong, Jin-Tang: 1 article (04/2008)

Related Diseases

1.	Prostatic Neoplasms (Prostate Cancer) 04/01/2008 - "Of the 11 genes located in this minimal deletion region and expressed in normal prostates, only snoRNA U50 was mutated, demonstrated transcriptional downregulation and inhibited colony formation in prostate cancer cells. " 04/01/2008 - "SnoRNA U50 is a candidate tumor-suppressor gene at 6q14.3 with a mutation associated with clinically significant prostate cancer." 08/01/2009 - "Based on a recent study identifying snoRNA U50 as a candidate for the 6q14-16 tumor suppressor gene in prostate cancer, we investigated whether U50 is also involved in breast cancer. " 04/01/2008 - "These findings establish snoRNA U50 as a reasonable candidate for the 6q tumor-suppressor gene in prostate cancer and likely in other types of cancers." Order ALL the reference details at left...
2.	Malaria 01/01/2009 - "CONCLUSION: This study provides a comprehensive overview on trans-acting genes involved in ribosome biogenesis and also a genetic insight into malaria parasite snoRNA genes." 01/01/2009 - "RESULTS: This is a comprehensive analysis of malaria parasite snoRNA genes and proteins that have a role in ribosomal biogenesis. " Order ALL the reference details at left...
3.	Breast Neoplasms (Breast Cancer) 08/01/2009 - "These results suggest that noncoding snoRNA U50 plays a role in the development and/or progression of breast cancer." 08/01/2009 - "Implication of snoRNA U50 in human breast cancer." 08/01/2009 - "Based on a recent study identifying snoRNA U50 as a candidate for the 6q14-16 tumor suppressor gene in prostate cancer, we investigated whether U50 is also involved in breast cancer. " Order ALL the reference details at left...
4.	Prader-Willi Syndrome (Syndrome, Prader-Willi) 11/15/2009 - "Deficiency of the paternal 15q11-q13 snoRNA HBII-85 locus is necessary to cause the neurodevelopmental disorder Prader-Willi syndrome (PWS). " 01/01/2006 - "Furthermore, several reports link the disruption of expression of a specific b-snoRNA, HBII-85, with a neurobehavioral disorder, Prader-Willi syndrome. " 06/01/2005 - "Lack of Pwcr1/MBII-85 snoRNA is critical for neonatal lethality in Prader-Willi syndrome mouse models." 02/01/2005 - "Exclusion of the C/D box snoRNA gene cluster HBII-52 from a major role in Prader-Willi syndrome." 02/15/2001 - "Large-scale evaluation of imprinting status in the Prader-Willi syndrome region: an imprinted direct repeat cluster resembling small nucleolar RNA genes." Order ALL the reference details at left...
5.	Genetic Translocation (Chromosomal Translocation) 04/01/2000 - "RESULTS: We found a novel intronic snoRNA gene, named U50HG, located on chromosome 6q15, at the breakpoint of chromosomal translocation t(3;6)(q27;q15). " 04/01/2000 - "It is novel to find that the snoRNA gene is located at the breakpoint of chromosomal translocation t(3;6)(q27;q15) involved in human B-cell lymphoma." 06/01/2008 - "Balanced chromosomal translocations that preserve expression of SNURF-SNRPN and centromeric genes but separate the snoRNA HBII-85 cluster from its promoter cause PWS. " 12/28/2007 - "Based on the analysis of deletions in the mouse and gene expression in PWS patients with chromosomal translocations, a critical region (PWScr) for neonatal lethality, failure to thrive, and growth retardation was narrowed to the locus containing a cluster of neuronally expressed MBII-85 small nucleolar RNA (snoRNA) genes. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Small Nucleolar RNA (snoRNA)
2.	Messenger RNA (mRNA)
3.	snRNP Core Proteins
4.	HSC70 Heat-Shock Proteins
5.	Macromolecular Substances
6.	Ribosomal RNA
7.	RNA Precursors (Precursor, mRNA)
8.	Proteins (Proteins, Gene)
9.	Histones (Histone)
10.	fibrillarin

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