Levodopa-responsive retrocollis on the background of choreic dyskinesia.

Abstract

Purpose/aim: Retrocollis can substantially disturb the daily living of individuals with Parkinson's disease (PD). Clinician often encounter the difficulty in managing the retrocollis. Materials and Methods: We describe a patient with PD who presented with choreic dyskinesia and levodopa-responsive retrocollis. Results: The patient had dyskinesia and the off periods, and received levodopa (700 mg, 14 times/day). The patient received levodopa-carbidopa intestinal gel (LCIG) treatment. After several months, the patient complained of difficulty in swallowing and speech due to severe retrocollis. Thirty minutes following a fast levodopa infusion of LCIG, the retrocollis improved. As a result, a frontal view was obtained, and her talking abilities showed improvement. Conclusions: Severe retrocollis can be superimposed on choreic dyskinesia, and it was likely to increase during the off periods. Duodenal levodopa infusion may reduce the severity of retrocollis.

• Authors: Hiroshi Kataoka, Yasuhiko Sawada, Naotaka Shimozato, Shinichiro Inatomi, Hitoshi Yoshiji, Kazuma Sugie
• Journal: The International journal of neuroscience (Int J Neurosci) Vol. 130 Issue 5 Pg. 461-463 (May 2020) ISSN: 1563-5279 [Electronic] England
• PMID: 31714814 (Publication Type: Case Reports, Journal Article)

Chemical References

• Antiparkinson Agents
• Drug Combinations
• carbidopa, levodopa drug combination
• Levodopa
• Carbidopa

Topics

• Aged
• Antiparkinson Agents (administration & dosage, pharmacology)
• Carbidopa (administration & dosage, pharmacology)
• Chorea (drug therapy, etiology)
• Drug Combinations
• Female
• Humans
• Infusions, Parenteral
• Levodopa (administration & dosage, pharmacology)
• Parkinson Disease (complications, drug therapy)
• Torticollis (drug therapy, etiology)