Metastasis Associated Lung Adenocarcinoma Transcript 1: An update on expression pattern and functions in carcinogenesis.

Abstract

The Metastasis Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is among long non-coding RNAs (lncRNAs) which has disapproved the old term of "junk DNA" which was used for majority of human genome which are not transcribed to proteins. An extensive portion of literature points to the fundamental role of this lncRNA in tumorigenesis process of diverse cancers ranging from solid tumors to leukemia. Being firstly identified in lung cancer, it has prognostic and diagnostic values in several cancer types. Consistent with the proposed oncogenic roles for this lncRNA, most of studies have shown up-regulation of MALAT1 in malignant tissues compared with non-malignant/normal tissues of the same source. However, few studies have shown down-regulation of MALAT1 in breast cancer, endometrial cancer, colorectal cancer and glioma. In the current study, we have conducted a comprehensive literature search and provided an up-date on the role of MALAT1 in cancer biology. Our investigation underscores a potential role as a diagnostic/prognostic marker and a putative therapeutic target for MALAT1.

• Authors: Soudeh Ghafouri-Fard, Asghar Ashrafi Hafez, Mohammad Taheri
• Journal: Experimental and molecular pathology (Exp Mol Pathol) Vol. 112 Pg. 104330 (02 2020) ISSN: 1096-0945 [Electronic] Netherlands
• PMID: 31712117 (Publication Type: Journal Article, Meta-Analysis, Research Support, Non-U.S. Gov't)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Biomarkers, Tumor
• MALAT1 long non-coding RNA, human
• RNA, Long Noncoding

Topics

• Biomarkers, Tumor (genetics)
• Carcinogenesis (genetics)
• Cell Proliferation (genetics)
• Gene Expression Regulation, Neoplastic (drug effects)
• Genome, Human (genetics)
• Humans
• Neoplasms (drug therapy, genetics, pathology)
• Prognosis
• RNA, Long Noncoding (genetics)