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Intergenic DNA (Junk DNA)

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Any of the DNA in between gene-coding DNA, including untranslated regions, 5' and 3' flanking regions, INTRONS, non-functional pseudogenes, and non-functional repetitive sequences. This DNA may or may not encode regulatory functions.

Also Known As:

Junk DNA; Intergenic Regions; Intergenic Region; Spacer DNA; DNA, Intergenic; Intercistronic Region; Intercistronic Sequence; Intergenic Sequence; Sequence, Intergenic; DNAs, Intergenic; DNAs, Junk; DNAs, Spacer; Intercistronic Regions; Intercistronic Sequences; Intergenic DNAs; Intergenic Sequences; Junk DNAs; Region, Intercistronic; Region, Intergenic; Regions, Intercistronic; Regions, Intergenic; Sequence, Intercistronic; Sequences, Intercistronic; Sequences, Intergenic; Spacer DNAs; DNA, Junk; DNA, Spacer

Networked: 158 relevant articles (2 outcomes, 5 trials/studies) for this Bio-Agent, Comments

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Bio-Agent Context: Research Results

Experts

1.	Hellen, Christopher U T: 3 articles (07/2005 - 09/2004)
2.	Thompson, Sunnie R: 2 articles (12/2009 - 05/2009)
3.	Landry, Dori M: 2 articles (12/2009 - 05/2009)
4.	Zhang, Ren: 2 articles (01/2008 - 06/2004)
5.	Zhang, Chun-Ting: 2 articles (01/2008 - 06/2004)
6.	Sabeta, C T: 2 articles (10/2007 - 03/2005)
7.	Pestova, Tatyana V: 2 articles (07/2005 - 09/2004)
8.	Roy, Sougata: 2 articles (04/2005 - 12/2004)
9.	Ajitkumar, Parthasarathi: 2 articles (04/2005 - 12/2004)
10.	Sarnow, Peter: 2 articles (12/2002 - 05/2002)

Related Diseases

1.	Contagious Ecthyma (Orf) 04/01/2010 - "Computer based analysis, recombination detection Program (RDP) supports the recombination hypothesis, indicated that recombination with other begomoviruses had taken place within V1 ORF and AC1 ORF of CLCuV-SG01 and AC1 ORF of CLCuV-SG02 and also in noncoding intergenic region (IR)." 02/01/2010 - "The size and number of the integration experiments resulted in reproducible measures of integration for each intergenic region and ORF in the S. " 10/27/2009 - "These capped, polyadenylated ncRNAs are transcribed across the large intergenic region upstream of the FLO11 ORF. " 05/01/2009 - "The general design of desired construction provides the conversion of the original two-cistronic operon into three-cistronic operon with translational-coupled genes, where the coupling of the artificial ORF (rplD'-lambdaattB-'trpE) with the proximal gene is occurred due to rplC-rplD intercistronic region and the coupling of this ORF with the distal gene--due to trpE-trpD. " 02/01/2009 - "The intergenic region between ORF 62 and ORF 63 was amplified by PCR and sequenced. " Order ALL the reference details at left...
2.	Shock 02/01/1992 - "Transgenes that eliminated one promoter from a gene pair were expressed at reduced levels, particularly in postembryonic stages, suggesting that the heat shock elements in the intergenic region of an hsp16 gene pair may act cooperatively to achieve high levels of expression of both genes. " 05/01/2007 - "Identification of transcription elements in the 5' intergenic region shared by LON and MDJ1 heat shock genes from the human pathogen Paracoccidioides brasiliensis. " 05/24/1996 - "YAR1 shares an intergenic region with HSP82, and while HSP82 transcription is induced 15-fold by heat shock, transcription of YAR1 is transiently repressed by heat shock. " 11/01/1989 - "Within this sequence are a number of elements conserved with the trypanosome hsp70 intergenic region, including a 14-nt sequence that also has homology to the Drosophila heat-shock consensus element." 09/13/1996 - "Methanosarcina mazei, using a segment (Int alpha; 1015 bp) which encompasses the intergenic region (431 bp) between the stress (heat-shock) genes grpE and dnaK. " Order ALL the reference details at left...
3.	Tuberculosis 04/01/2005 - "tuberculosis ftsZ and promoter fusion studies identified six ftsZ transcripts and their promoters in the ftsQ open reading frame and ftsQ-ftsZ intergenic region. " 08/01/2009 - "tuberculosis we have identified nine putative sRNA molecules, including cis-encoded antisense transcripts from within open reading frames and trans-encoded transcripts from intergenic regions. " 01/01/2009 - "tuberculosis strains contain mutations at embB codons 306, 406 and 497, embC-embA intergenic region (IGR) and iniA codon 501 (iniA501). " 08/01/2007 - "OBJECTIVE: To develop a system for the molecular diagnosis of tuberculosis by polymerase chain reaction (PCR), constructing primers based on the difference in gene organization of the intergenic region of phospholipase C (plcB-plcC region), which differentiates Mycobacterium tuberculosis from other mycobacteria. " 06/11/1999 - "tuberculosis oriC plasmids did not abolish their ability to function as oriC, confirming that the autonomous replication activity of these plasmids is due to the presence of the DNA fragment containing the dnaA-dnaN intergenic region. " Order ALL the reference details at left...
4.	beta-Thalassemia (Cooley's Anemia) 10/15/2009 - "Genetic studies have identified three major quantitative trait loci (QTLs) (Xmn1-HBG2, HBS1L-MYB intergenic region on chromosome 6q23, and BCL11A on chromosome 2p16) that account for 20-50% of the common variation in HbF levels in patients with SCA and beta thalassemia, and in healthy adults. " 04/01/2006 - "RESULTS: We established that (i) the combination: T haplotype of the Agamma-delta-globin intergenic region, the motif (TA)9N10(TA)10 in the HS2 site of locus control region (LCR), and TAG pre-Ggamma haplotype is sufficient but not necessary for high HbF, (ii) the genetic determinant(s) for high HbF involves an element associated with this combination and must be present in the specific R haplotype occurring in beta-thalassemia intermedia and (iii) the genetic determinant(s) for high HbF does not involve the abolition of intergenic transcription in the Agamma-delta-globin intergenic region. " 08/15/2001 - "It results from a 7.4-kb deletion that removes the delta-globin coding sequences, the delta beta intergenic region as well as the beta-globin gene promoter and causes delta(0)beta(+) thalassemia with hemoglobin A expressed at the 11% to 15% range. " 01/01/1989 - "This paper describes individuals of Sardinian descent with heterozygous normal-Hb A2 beta-thalassemia who have a chromosome with a 7.2 Kb deletion in the psi beta/delta globin intergenic region and a chromosome with the codon 39 nonsense mutation. " Order ALL the reference details at left...
5.	Obesity 12/01/2009 - "Meta-analysis of genomic coordinates of SNP variations identified in genome-wide association studies (GWAS) of up to 712,253 samples (comprising 221,158 disease cases, 322,862 controls, and 168,233 case/control subjects of obesity GWAS) reveals that 39% of SNPs associated with 22 common human disorders are located within intergenic regions. " 01/01/2009 - "BACKGROUND: We explored the associations of three variants in the uncoupling protein 2 (UCP2) gene, one variant in the UCP2-UCP3 intergenic region and five variants in the uncoupling protein 3 (UCP3) gene with obesity and diabetes related traits in subjects with impaired glucose tolerance participating in Finnish Diabetes Prevention Study. " Order ALL the reference details at left...

Related Drugs and Biologics

1.	Aminosalicylic Acid (PAS)
2.	DNA (Deoxyribonucleic Acid)
3.	Glucose (Dextrose)
4.	Antigens
5.	RNA (Ribonucleic Acid)
6.	Messenger RNA (mRNA)
7.	Deoxyribonuclease I (Nickase)
8.	5' Untranslated Regions (5' UTR)
9.	Proteins (Proteins, Gene)
10.	Codon (Codons)

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