Galanin peptide family regulation of glucose metabolism.

Abstract

Recent preclinical and clinical studies have indicated that the galanin peptide family may regulate glucose metabolism and alleviate insulin resistance, which diminishes the probability of type 2 diabetes mellitus. The galanin was discovered in 1983 as a gut-derived peptide hormone. Subsequently, galanin peptide family was found to exert a series of metabolic effects, including the regulation of gut motility, body weight and glucose metabolism. The galanin peptide family in modulating glucose metabolism received recently increasing recognition because pharmacological activiation of galanin signaling might be of therapeutic value to improve insuin resistance and type 2 diabetes mellitus. To date, however, few papers have summarized the role of the galanin peptide family in modulating glucose metabolism and insulin resistance. In this review we summarize the metabolic effect of galanin peptide family and highlight its glucoregulatory action and discuss the pharmacological value of galanin pathway activiation for the treatment of glucose intolerance and type 2 diabetes mellitus.

• Authors: Penghua Fang, Mei Yu, Mingyi Shi, Ping Bo, Zhenwen Zhang
• Journal: Frontiers in neuroendocrinology (Front Neuroendocrinol) Vol. 56 Pg. 100801 (01 2020) ISSN: 1095-6808 [Electronic] United States
• PMID: 31705911 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't, Review)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• GAL protein, human
• Galanin-Like Peptide
• Peptide Hormones
• Receptors, Galanin
• SPX protein, human
• alarin
• Galanin
• Glucose

Topics

• Animals
• Diabetes Mellitus, Type 2 (drug therapy)
• Female
• Galanin (physiology)
• Galanin-Like Peptide (physiology)
• Glucose (metabolism)
• Glucose Intolerance (drug therapy)
• Humans
• Insulin Resistance (physiology)
• Male
• Mice
• Peptide Hormones (physiology)
• Receptors, Galanin (physiology)
• Sex Factors