Abstract | BACKGROUND: OBJECTIVE: The present study aimed to compare cognitive performances and neuropsychiatric symptoms in a population of AD, bvFTD, and left and right SD defined with the support of molecular imaging ( amyloid and 2-[18F] fluoro- 2-deoxy-D-glucose positron emission tomography) and assessed the accuracy of different neuropsychological markers in distinguishing these neurodegenerative diseases. METHODS: Eighty-seven participants (32 AD, 20 bvFTD, and 35 SD (17 Left-SD and 18 Right-SD) completed a comprehensive neuropsychological battery that included memory, language, attention and executive functions, visuospatial function, visuoconstructional skills, and tasks designed specifically to evaluate prosopagnosia and facial emotions recognition. The Neuropsychiatric Inventory was administered to assess neuropsychiatric symptoms. RESULTS: An episodic memory test that included semantic cues, a visuospatial test (both impaired in AD), a naming test and a prosopagnosia task (both impaired in SD) were the four most valuable cognitive metrics for the differential diagnosis between groups. Several behavioral abnormalities were differentially present, of which aggression, self-care (both more frequent in bvFTD), and eating habits, specifically overeating and altered dietary preference (more frequent in SD), were the most valuable in group discrimination. CONCLUSION: Our study highlights the value of a comprehensive neuropsychological and neuropsychiatric evaluation for the differential diagnosis between FTD syndromes and AD.
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Authors | Ana Pozueta, Carmen Lage, María García-Martínez, Martha Kazimierczak, María Bravo, Sara López-García, Javier Riancho, Andrea González-Suarez, José Luis Vázquez-Higuera, María de Arcocha-Torres, Ignacio Banzo, Julio Jiménez-Bonilla, José Berciano, Eloy Rodríguez-Rodríguez, Pascual Sánchez-Juan |
Journal | Journal of Alzheimer's disease : JAD
(J Alzheimers Dis)
Vol. 72
Issue 4
Pg. 1129-1144
( 2019)
ISSN: 1875-8908 [Electronic] Netherlands |
PMID | 31683488
(Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
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Topics |
- Aged
- Aged, 80 and over
- Alzheimer Disease
(diagnosis, diagnostic imaging, psychology)
- Brain
(diagnostic imaging)
- Cognition
(physiology)
- Dementia
(diagnosis, diagnostic imaging, psychology)
- Diagnosis, Differential
- Executive Function
(physiology)
- Female
- Frontotemporal Dementia
(diagnosis, diagnostic imaging, psychology)
- Humans
- Male
- Memory
(physiology)
- Middle Aged
- Neuropsychological Tests
- Positron-Emission Tomography
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