Fully automated preparation of 68Ga-PSMA-11 at curie level quantity using cyclotron-produced 68Ga for clinical applications.

Abstract

68Ga-PSMA-11 is currently one of the most investigated PET agents for imaging both recurrent prostate cancer and relevant metastases; however, the production and distribution of 68Ga-PSMA-11 is limited to a supply of only a few daily doses when using a commercially available 68Ge/68Ga generator. 68Ge/68Ga generators deliver only a modest amount of activity, up to 1850 MBq (50 mCi), when new, but it decreases with time. Additionally, the production of 68Ga/68Ge generators has not been able to meet the increasing demand of 68Ga radiotracers. In response to the need for a more economically viable alternative, the focus of this study was to provide a simple and efficient method for producing 68Ga-PSMA-11, using cyclotron-produced 68Ga that is ready for routine clinical practice.

• Authors: Mai Lin, Vincenzo Paolillo, Robert T Ta, Jossana Damasco, Raniv Dawey Rojo, James C Carl, Marites P Melancon, Gregory C Ravizzini, Dao B Le, Elmer B Santos
• Journal: Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine (Appl Radiat Isot) Vol. 155 Pg. 108936 (Jan 2020) ISSN: 1872-9800 [Electronic] England
• PMID: 31655351 (Publication Type: Journal Article)
• Copyright: Published by Elsevier Ltd.

Chemical References

• Gallium Isotopes
• Gallium Radioisotopes
• Membrane Glycoproteins
• Organometallic Compounds
• gallium 68 PSMA-11

Topics

• Automation
• Cell Line, Tumor
• Cyclotrons
• Gallium Isotopes
• Gallium Radioisotopes
• Humans
• Male
• Membrane Glycoproteins (chemistry)
• Organometallic Compounds (chemistry)