The impact of dyslipidemia and oxidative stress on vasoactive mediators in patients with renal dysfunction.

Abstract

Hyperlipidemia and oxidative stress are indispensable features of chronic kidney disease (CKD) that favor the development of atherogenic plaques and cardiovascular disease (CVD). A number of vasoactive mediators including proprotein convertase subtilisin-kexin type 9 (PCSK9), endothelin-1, nitric oxide, and angiotensin II have fundamental roles in the pathophysiology of atherosclerotic events; moreover, their levels are affected by dyslipidemia and oxidative stress due to renal dysfunction. Therefore, therapeutic measures aimed at correcting dyslipidemia and alleviating oxidative stress could potentially protect against CVD in CKD patients. In this review, we discuss the relation between dyslipidemia, oxidative stress, and vasoactive mediators as well as the available treatment options against these disturbances in CKD patients.

• Authors: Maryam Jabarpour, Nadereh Rashtchizadeh, Hassan Argani, Amir Ghorbanihaghjo, Masoumeh Ranjbarzadhag, Davoud Sanajou, Fatemeh Panah, Amirhesam Alirezaei
• Journal: International urology and nephrology (Int Urol Nephrol) Vol. 51 Issue 12 Pg. 2235-2242 (Dec 2019) ISSN: 1573-2584 [Electronic] Netherlands
• PMID: 31641998 (Publication Type: Journal Article, Review)

Chemical References

• Endothelin-1
• Angiotensin II
• Nitric Oxide
• PCSK9 protein, human
• Proprotein Convertase 9

Topics

• Angiotensin II (physiology)
• Dyslipidemias (complications, metabolism)
• Endothelin-1 (physiology)
• Humans
• Nitric Oxide (physiology)
• Oxidative Stress
• Proprotein Convertase 9 (physiology)
• Renal Insufficiency, Chronic (complications, metabolism)