Correlations of IL-6 and CRP gene polymorphisms with pulmonary heart disease.

Abstract

OBJECTIVE:

To explore the correlations of interleukin-6 (IL-6) and C-reactive protein (CRP) gene polymorphisms with pulmonary heart disease (PHD).

PATIENTS AND METHODS:

A total of 98 patients with PHD and 102 healthy persons receiving physical examinations were enrolled. Their general clinical information was collected, and the levels of IL-6 and CRP in the plasma were determined. The pulmonary functions and blood gas were detected, and the TaqMan-minor groove binder (MGB) probe was used to detect the polymorphisms of IL-6 rs1800796 and CRP rs1800796.

RESULTS:

Observation group had higher levels of IL-6 and CRP than control group (p<0.05). The forced expiratory volume in 1 second (FEV1) (%), FEV1/forced vital capacity (FVC) ratio (%), and arterial partial pressure of oxygen (PaO2) in observation group were lower than those in control group (p<0.05), but the arterial partial pressure of carbon dioxide (PaCO2) was higher than that in control group (p<0.05). There were differences in the distribution frequencies of the genotypes and alleles of IL-6 rs1800796 and CRP rs1800796 between the two groups (p<0.05).

CONCLUSIONS:

IL-6 and CRP are correlated with the onset of PHD, and there are also correlations between the polymorphisms of IL-6 rs1800796 and CRP rs2794521 and the disease.

• Authors: Y Wu, S-R Bai, S-J Wei, L-J Ge, S-J Xi
• Journal: European review for medical and pharmacological sciences (Eur Rev Med Pharmacol Sci) Vol. 23 Issue 18 Pg. 8109-8114 (Sep 2019) ISSN: 2284-0729 [Electronic] Italy
• PMID: 31599438 (Publication Type: Journal Article)

Chemical References

• IL6 protein, human
• Interleukin-6
• Carbon Dioxide
• C-Reactive Protein
• Oxygen

Topics

• Blood Gas Analysis
• C-Reactive Protein (genetics)
• Carbon Dioxide (metabolism)
• Case-Control Studies
• Female
• Forced Expiratory Volume
• Genetic Predisposition to Disease
• Humans
• Interleukin-6 (genetics)
• Male
• Middle Aged
• Oxygen (metabolism)
• Partial Pressure
• Polymorphism, Single Nucleotide
• Pulmonary Heart Disease (genetics, metabolism, physiopathology)
• Vital Capacity