Abstract | PURPOSE: METHODS: We performed a retrospective analysis (2011-2016) of a prospectively collected registry from two hospitals of consecutive ICU patients ≥ 18 years of age receiving invasive mechanical ventilation. CFS scores were based on recorded pre-admission function at the time of hospital admission. The primary outcome was hospital mortality. Secondary outcomes included discharge to long-term care, extubation failure at time of first liberation attempt, and tracheostomy. RESULTS: We included 8110 patients, and 2529 (31.2%) had frailty (CFS ≥ 5). Frailty was associated with increased odds of hospital death (adjusted odds ratio [aOR]: 1.24 [95% confidence interval [CI] 1.10-1.40) and discharge to long-term care (aOR 1.21 [95% CI 1.13-1.35]). As compared to patients without frailty, patients with frailty had increased odds of extubation failure (aOR 1.17 [95% CI 1.04-1.37]), hospital death following extubation failure (aOR 1.18 [95% CI 1.07-1.28]), tracheostomy (aOR 1.17 [95% CI 1.01-1.36]), and hospital death following tracheostomy (aOR 1.14 [95% CI 1.03-1.25]). CONCLUSIONS:
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Authors | Shannon M Fernando, Daniel I McIsaac, Bram Rochwerg, Sean M Bagshaw, John Muscedere, Laveena Munshi, Niall D Ferguson, Andrew J E Seely, Deborah J Cook, Chintan Dave, Peter Tanuseputro, Kwadwo Kyeremanteng |
Journal | Intensive care medicine
(Intensive Care Med)
Vol. 45
Issue 12
Pg. 1742-1752
(12 2019)
ISSN: 1432-1238 [Electronic] United States |
PMID | 31595352
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Aged
- Aged, 80 and over
- Airway Extubation
(adverse effects)
- Cohort Studies
- Critical Illness
(mortality)
- Female
- Frailty
(complications, mortality)
- Hospital Mortality
- Humans
- Male
- Middle Aged
- Odds Ratio
- Respiration, Artificial
(adverse effects)
- Respiratory Insufficiency
(mortality, therapy)
- Retrospective Studies
- Risk Factors
- Time Factors
- Tracheostomy
(methods)
- Treatment Outcome
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