Abstract | INTRODUCTION: METHODS: We performed a randomized crossover trial in which stable asthmatic patients controlled on ICS/LABA received 8 weeks of FF/VI (100/25 μg 1 puff once-daily) or BUD/FM (160/4.5 μg 2 puffs twice-daily) DPI treatment. After a 4-8-week washout period, patients received another crossover treatment for 8 weeks. We assessed pulmonary function, the 5-item version asthma control questionnaire (ACQ5), the asthma control test (ACT), and fractional exhaled nitric oxide (FeNO) at baseline and after 8 weeks of treatment (week 8). As the primary outcome was change in force expiratory volume in 1 s (FEV1) between baseline and week 8, we evaluated the incidence of asthma exacerbation and adherence barrier questionnaire (Ask-12) at week 8. RESULTS: Twenty-three patients were initially enrolled in this study; however, one patient had to be excluded. The FF/VI DPI treatment group showed a similar magnitude of change in FEV1 between baseline and week 8 as the BUD/FM DPI treatment group. In addition, there were no significant differences in pulmonary function tests, ACQ5 scores, ACT scores, and FeNO between baseline and week 8 in both groups. Although the incidence of exacerbation did not differ between groups, the Ask-12 score in the FF/VI DPI group was significantly lower than that in the BUD/FM DPI group. CONCLUSIONS: The present study indicates that once-daily FF/VI DPI is not inferior to twice-daily BUD/FM DPI in clinical effect and more likely to improve inconvenience and forgetfulness in inhalation adherence barriers for stable asthma control therapy. Once-daily FF/VI DPI may be an effective alternative for asthma maintenance treatment.
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Authors | Kazuki Furuhashi, Tomoyuki Fujisawa, Dai Hashimoto, Yousuke Kamiya, Hideki Yasui, Masato Karayama, Yuzo Suzuki, Hironao Hozumi, Noriyuki Enomoto, Yutaro Nakamura, Naoki Inui, Takafumi Suda |
Journal | Journal of asthma and allergy
(J Asthma Allergy)
Vol. 12
Pg. 253-261
( 2019)
ISSN: 1178-6965 [Print] New Zealand |
PMID | 31571932
(Publication Type: Journal Article, Review)
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Copyright | © 2019 Furuhashi et al. |