Abstract | OBJECTIVE: METHODS: Five groups of adult male Wistar rats (n=10), were randomly selected as control, placebo, experimental 1, 2 and 3. The induction of arthritis was carried out by injection of 0.1 ml adjuvant in plantar region. The first experimental group received no curcumin treatment, whereas the experimental two and three received curcumin (1 and 2 g/kg daily) respectively, for fourteen days. MSRA gene expression was assessed by real-time PCR and protein levels of MSRA, SOD, CAT and GPx were analyzed via ELISA method. RESULTS: The results showed no significant weight changes among the groups during the experimental period and the paw swelling caused by adjuvant was recovered within fourteen days of treatment with curcumin. However, the levels of enzymes such as superoxide dismutase, catalase and glutathione peroxidase were increased by a dose dependent manner. These results also illustrated that the gene expression and protein level of MSRA in groups treated with curcumin increased significantly (p≤0.05). CONCLUSION: We concluded that the curcumin can be used against inflammation. The increasing level of MSRA can be due to the antioxidant effect of curcumin. The enzymatic level changes (MSRA, SOD, CAT and GPx) may interfere with the aging process and delay it.
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Authors | M H Meshkibaf, M Maleknia, S Noroozi |
Journal | Journal of inflammation research
(J Inflamm Res)
Vol. 12
Pg. 241-249
( 2019)
ISSN: 1178-7031 [Print] New Zealand |
PMID | 31564949
(Publication Type: Journal Article)
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Copyright | © 2019 Meshkibaf et al. |