Pharmacologic Management of Portal Hypertension.

Abstract

Terlipressin, somatostatin, or octreotide are recommended as pharmacologic treatment of acute variceal hemorrhage. Nonselective β-blockers decrease the risk of variceal hemorrhage and hepatic decompensation, particularly in those 30% to 40% of patients with good hemodynamic response. Carvedilol, statins, and anticoagulants are promising agents in the management of portal hypertension. Recent advances in the pharmacologic treatment of portal hypertension have mainly focused on modifying an increased intrahepatic resistance through nitric oxide and/or modulation of vasoactive substances. Several novel pharmacologic agents for portal hypertension are being evaluated in humans.

• Authors: Chalermrat Bunchorntavakul, K Rajender Reddy
• Journal: Clinics in liver disease (Clin Liver Dis) Vol. 23 Issue 4 Pg. 713-736 (11 2019) ISSN: 1557-8224 [Electronic] United States
• PMID: 31563219 (Publication Type: Journal Article, Review)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Adrenergic alpha-1 Receptor Antagonists
• Adrenergic beta-Antagonists
• Anticoagulants
• Antihypertensive Agents
• Gastrointestinal Agents
• Hydroxymethylglutaryl-CoA Reductase Inhibitors
• Nitrates
• Vasodilator Agents
• Carvedilol
• Somatostatin
• Terlipressin
• Propranolol
• Octreotide

Topics

• Adrenergic alpha-1 Receptor Antagonists (therapeutic use)
• Adrenergic beta-Antagonists (therapeutic use)
• Anticoagulants (therapeutic use)
• Antihypertensive Agents (therapeutic use)
• Carvedilol (therapeutic use)
• Esophageal and Gastric Varices (etiology)
• Gastrointestinal Agents (therapeutic use)
• Gastrointestinal Hemorrhage (etiology, prevention & control, therapy)
• Hemostasis, Endoscopic
• Humans
• Hydroxymethylglutaryl-CoA Reductase Inhibitors (therapeutic use)
• Hypertension, Portal (complications, drug therapy)
• Nitrates (therapeutic use)
• Octreotide (therapeutic use)
• Propranolol (therapeutic use)
• Somatostatin (therapeutic use)
• Terlipressin (therapeutic use)
• Vasodilator Agents (therapeutic use)