NACHT, LRR, and PYD domains-containing Protein 3 and LL-37: prognostic value of new biomarkers in community-acquired pneumonia.

Abstract

OBJECTIVE:

This study aimed to determine the serum levels of NACHT, Leucine-rich repeat (LRR), and Pyrin (PYD) domains-containing Protein 3 (NLRP3) and cathelicidin LL-37, and investigate their prognostic significance in community-acquired pneumonia (CAP).

METHODS:

The sample of this prospective study was composed of 76 consecutive patients with CAP. Demographic data and clinical characteristics were collected. Serum levels of NLRP3 and LL-37 were determined by ELISA. Spearman's analysis was used to evaluate the correlation between NLRP3 and LL-37. Association of NLRP3 and LL-37 with 30-day survival and mortality rates was assessed using the Kaplan-Meier curve and logistic regression analysis.

RESULTS:

Serum NLRP3 significantly increased whereas serum LL-37 significantly decreased in patients with severe CAP. Significant correlation was observed between serum NLRP3 and LL-37 in CAP patients. Patients with higher levels of NLRP3 and lower levels of LL-37 showed lower 30-day survival rate and higher mortality compared with those with lower NLRP3 and higher LL-37 levels.

CONCLUSION:

Severe CAP patients tend to present higher serum NLRP3 and lower serum LL-37, which might serve as potential biomarkers for CAP prognosis.

• Authors: Chuanan Zhu, Yingfan Zhou, Jiabin Zhu, Ye Liu, Mengyi Sun
• Journal: Jornal brasileiro de pneumologia : publicacao oficial da Sociedade Brasileira de Pneumologia e Tisilogia (J Bras Pneumol) Vol. 45 Issue 4 Pg. e20190001 (Aug 29 2019) ISSN: 1806-3756 [Electronic] Brazil
• Vernacular Title: Proteína 3 contendo um domínio NACHT, porção C-terminal rica em repetições de leucina e de domínio pirina e LL-37: valor prognóstico de novos biomarcadores em pneumonia adquirida na comunidade.
• PMID: 31482943 (Publication Type: Journal Article)

Chemical References

• Antimicrobial Cationic Peptides
• Biomarkers
• Leucine-Rich Repeat Proteins
• NLR Family, Pyrin Domain-Containing 3 Protein
• Proteins
• Pyrin
• Cathelicidins

Topics

• Aged
• Antimicrobial Cationic Peptides (blood)
• Biomarkers (blood)
• Case-Control Studies
• Community-Acquired Infections (blood, mortality)
• Female
• Humans
• Kaplan-Meier Estimate
• Leucine-Rich Repeat Proteins
• Logistic Models
• Male
• Middle Aged
• Multivariate Analysis
• NLR Family, Pyrin Domain-Containing 3 Protein (blood)
• Pneumonia (blood, mortality)
• Predictive Value of Tests
• Prospective Studies
• Proteins (analysis)
• Pyrin (blood)
• Reference Values
• Risk Assessment
• Risk Factors
• Time Factors
• Cathelicidins