Abstract | BACKGROUND: MATERIALS AND METHODS: RESULTS: The levels of transaminases 24 hours after Hx were significantly reduced in the group pretreated with bevacizumab compared to that not pretreated (p<0.05). The liver regeneration rate at 24 hours after Hx was significantly increased in the group pretreated with bevacizumab compared with the group which underwent Hx alone (p<0.05). The survival rate for the group pretreated with bevacizumab tended to be higher than that of the Hx-only group, 72 hours after Hx (p=0.09). The expressions of Il1b, Mmp2 and Mmp9 mRNA 24 hours after Hx in the group pretreated with bevacizumab tended to be lower than that of rats which underwent Hx alone (p=0.11, 0.09 and 0.15, respectively). The expression of Xbp1, Chop, Grp78 and Hsp70 mRNA immediately before Hx in the group pretreated with bevacizumab were significantly higher than the 90% Hx group (p<0.05). CONCLUSION:
Bevacizumab pretreatment had protective effects on liver injury after massive hepatectomy in rats, apparently via the induction of the endoplasmic reticulum stress response, i.e. the so-called unfolded protein response.
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Authors | Hiroki Mori, Y U Saito, Shuichi Iwahashi, Tetsuya Ikemoto, Satoru Imura, Yuji Morine, Mitsuo Shimada |
Journal | In vivo (Athens, Greece)
(In Vivo)
2019 Sep-Oct
Vol. 33
Issue 5
Pg. 1469-1476
ISSN: 1791-7549 [Electronic] Greece |
PMID | 31471394
(Publication Type: Journal Article)
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Copyright | Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved. |
Chemical References |
- Antineoplastic Agents, Immunological
- Biomarkers
- Cytokines
- Bevacizumab
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Topics |
- Animals
- Antineoplastic Agents, Immunological
(adverse effects)
- Bevacizumab
(adverse effects)
- Biomarkers
- Chemical and Drug Induced Liver Injury
(etiology, pathology)
- Cytokines
(genetics, metabolism)
- Gene Expression
- Hepatectomy
- Liver
(drug effects, pathology, surgery)
- Liver Function Tests
- Liver Regeneration
- Male
- Postoperative Period
- Rats
- Time Factors
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