Anti-Inflammatory Effects of Phenolic Compounds Isolated from Quercus Mongolica Fisch. ex Ledeb. on UVB-Irradiated Human Skin Cells.

Abstract

Quercus mongolica Fisch. ex Ledeb. (QM) has been used as an oriental traditional medicine to relieve hemorrhoids, fever, and enteritis. We screened the inhibitory activities of the extracts and compounds (1-6) isolated from QM on the production of inflammatory cytokines and chemokines to evaluate their anti-inflammatory activities. Further, we evaluated the expression levels of cytokines, chemokines, and immune factors on pedunculagin (PC, 1), which was selected from isolated compounds (1-6) because of its potential anti-inflammation effect. Additionally, we evaluated whether the inflammation mitigation effects of PC (1) following UVB exposure in keratinocytes occurred because of nuclear factor (NF)-κB and signal transducer and activator of transcription (STAT)/Janus kinase (JAK) activation. PC (1) remarkably suppressed interleukin (IL)-6, IL-10, IL-13, and monocyte chemoattractant protein-1 (MCP-1) mRNA expression and reduced the mRNA expression level of Cyclooxygenase-2 (COX-2) and also reduced the phosphorylation of p38 mitogen-activated protein kinases (p38), c-Jun N-terminal kinase (JNK), and extracellular signal-regulated kinase (ERK) in a concentration-dependent manner.

• Authors: Jun Yin, Han Hyuk Kim, In Hyeok Hwang, Dong Hee Kim, Min Won Lee
• Journal: Molecules (Basel, Switzerland) (Molecules) Vol. 24 Issue 17 (Aug 26 2019) ISSN: 1420-3049 [Electronic] Switzerland
• PMID: 31454971 (Publication Type: Journal Article)

Chemical References

• Anti-Inflammatory Agents
• Cytokines
• Lipopolysaccharides
• NF-kappa B
• Phenols
• Plant Extracts
• Tannins
• pedunculagin

Topics

• Anti-Inflammatory Agents (chemistry, pharmacology)
• Cell Line
• Cells, Cultured
• Cytokines (genetics, metabolism)
• Drug Evaluation, Preclinical
• Gene Expression Regulation (drug effects)
• Humans
• Keratinocytes (cytology, drug effects, radiation effects)
• Lipopolysaccharides (adverse effects)
• NF-kappa B
• Phenols (chemistry, pharmacology)
• Phosphorylation
• Plant Extracts (chemistry, pharmacology)
• Quercus (chemistry)
• Signal Transduction (drug effects)
• Tannins (chemistry, pharmacology)
• Ultraviolet Rays (adverse effects)