Glycogen Synthase Kinase-3β Inhibitor Attenuates Renal Damage Through Regulating Antioxidant and Anti-inflammation in Rat Kidney Transplant With Cold Ischemia Reperfusion.
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| Abstract | BACKGROUD: The glycogen synthase kinase-3β inhibitor thiadiazolidinone derivative 8 (TDZD-8) has been reported to reduce renal ischemia reperfusion (I/R) injury through inhibiting cell damage. However, it is not known whether TDZD-8 could also play a role in protecting the kidney in rat kidney transplantation with renal cold I/R. The aim of the present study was to explore the possible role of TDZD-8 in protecting renal damage in a cold I/R model of rat kidney transplantation. METHODS: The rat model of kidney transplantation with renal cold I/R was established. The renal tissue pathomorphologic changes, renal function, oxidative stress, and inflammatory response were evaluated by detection of a series of indices by hematoxylin and eosin staining, commercial kits, enzyme-linked immunosorbent assay, and spectrophotofluorometry, respectively. RESULTS: Compared with I/R and Graft groups, renal function was significantly improved in TDZD and TDZD-G groups, which were accompanied by the reduction of renal injury, oxidative stress, and inflammation. CONCLUSIONS: These results suggest that preconditioning with glycogen synthase kinase-3β inhibitor can attenuate kidney transplantation with renal cold I/R through regulating endogenous antioxidant activity and inflammation.
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| Authors | Bo Hu, Jie Tang, Yi Zhang, Zhenyi Ma, Yungang Shan, Jie Liu, Xiaohua Shen, Ping Qian |
| Journal | Transplantation proceedings (Transplant Proc) 2019 Jul - Aug Vol. 51 Issue 6 Pg. 2066-2070 ISSN: 1873-2623 [Electronic] United States |
| PMID | 31399185 (Publication Type: Journal Article) |
| Copyright | Copyright © 2019 Elsevier Inc. All rights reserved. |
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