IL-17F expression correlates with clinicopathologic factors and biological markers in non-small cell lung cancer.

Abstract

Interleukin-17 F (IL-17F) is a pro-inflammatory cytokine that participate in inflammatory responses. Studies showed that IL-17F is likely involved in tumor development, but the biological function of IL-17F in non-small cell lung cancer (NSCLC) is unclear. The aim of this study was to explore the biological role of IL-17F in NSCLC and investigate its correlation with biological markers CD31, P53, Ki-67 and E-cadherin. Paraffin-embedded tumor tissues from 55 NSCLC patients were collected to detect proteins expression using immunohistochemistry (IHC). 12 normal lung tissues samples were used as control. IHC results showed that the expression of IL-17F in NSCLC cells (61.8%) was significantly higher compared with normal lung tissues (25.0%) (P <  0.05). The expression of IL-17F was positively associated with tumor differentiation and negatively associated with lymph node metastasis and TNM staging (P all < 0.05). Multivariate analysis showed that IL-17F expression was an independent factor associated with TNM staging (P <  0.01). Pearson's correlation analysis showed a negative correlation between IL-17F and CD31 expression and a positive correlation between IL-17F and E-cadherin expression (P all < 0.05). There was no relationship between IL-17 F and P53 or Ki-67 expression in NSCLC tissues (P >  0.05). These data suggest that IL-17 F may be considered as a potential marker for predicting the progression of NSCLC.

• Authors: Chun Li, Xuzhe Ma, Cuisong Tan, Hui Fang, Ying Sun, Xiaodong Gai
• Journal: Pathology, research and practice (Pathol Res Pract) Vol. 215 Issue 10 Pg. 152562 (Oct 2019) ISSN: 1618-0631 [Electronic] Germany
• PMID: 31387805 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier GmbH. All rights reserved.

Chemical References

• Biomarkers, Tumor
• Cadherins
• Interleukin-17
• Ki-67 Antigen

Topics

• Adult
• Aged
• Biomarkers, Tumor (metabolism)
• Cadherins (metabolism)
• Carcinoma, Non-Small-Cell Lung (metabolism, pathology)
• Female
• Humans
• Interleukin-17 (metabolism)
• Ki-67 Antigen (metabolism)
• Lung (metabolism, pathology)
• Lung Neoplasms (metabolism, pathology)
• Lymphatic Metastasis (pathology)
• Male
• Middle Aged
• Neoplasm Staging