Luteolin inhibits CVB3 replication through inhibiting inflammation.

Abstract

Coxsackievirus B3 (CVB3) infection causes many inflammation-related diseases, such as viral myocarditis and aseptic meningitis. However, no vaccines or drugs have been approved for prevention or therapy of CVB3-induced diseases. In this study, luteolin (3,4,5,7-tetrahydroxyflavone) had been found that could dose-dependently reduce the production of viral progeny and synthesis of CVB3 RNA and protein. The luteolin-mediated inhibition of CVB3 was found to be mechanistically possible, at least in part, through depressing the phosphorylation of p38 MAPK and JNK MAPK, and inhibiting NF-κB nuclear translocation and subsequently attenuated the expression of inflammatory cytokines in CVB3-infected cells. Luteolin may be a potential agent or supplement against CVB3 infection by inhibiting inflammation.

• Authors: Shuo Wu, Hui-Qiang Wang, Ting-Ting Guo, Yu-Huan Li
• Journal: Journal of Asian natural products research (J Asian Nat Prod Res) Vol. 22 Issue 8 Pg. 762-773 (Aug 2020) ISSN: 1477-2213 [Electronic] England
• PMID: 31321999 (Publication Type: Journal Article)

Chemical References

• Luteolin

Topics

• Animals
• Enterovirus B, Human
• Inflammation
• Luteolin
• Mice
• Mice, Inbred BALB C
• Molecular Structure
• Virus Replication