Abstract | PURPOSE: METHODS: This was a randomized, parallel design, and clinical trial. Patients with IU/PU and cataract scheduled for cataract surgery were randomly assigned to receive the IVD concurrently with cataract surgery (Group 1: 20 patients) or systemic steroids (Group 2: 23 patients) tapered over 4-6 weeks along with uneventful cataract surgery and routine postoperative care. Patients with glaucoma/ contraindications to steroids were excluded. All patients were followed up for 6 months. OUTCOME MEASURE: Primary-incidence of postoperative CMO. Secondary-the change in BCVA (corrected distance visual acuity) and Central Subfield thickness (CST) and complications. Appropriate statistical analysis was done. RESULTS: The median age was 47.3 ± 4.23 years (group 1) and 49.12 ± 5.32 years (Group 2). One patient (Group 1) and two (Group 2) developed CMO. The BCVA improved significantly in both groups (p = 0.013). The CST change was insignificant. Four patients (Group 1) required intraocular pressure (IOP) lowering medications. Three patients (Group 2) required early steroid taper. CONCLUSIONS: IVD is a good alternative as prophylaxis in IU/PU and cataract in preventing postoperative CMO.
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Authors | Aditya Sudhalkar, Abhay Vasavada, Deepak Bhojwani, Viraj Vasavada, Shail Vasavada, Vaishali Vasavada, Samaresh Srivastava |
Journal | Eye (London, England)
(Eye (Lond))
Vol. 34
Issue 3
Pg. 491-498
(03 2020)
ISSN: 1476-5454 [Electronic] England |
PMID | 31320735
(Publication Type: Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't)
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Chemical References |
- Drug Implants
- Glucocorticoids
- Dexamethasone
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Topics |
- Adult
- Cataract
- Dexamethasone
(therapeutic use)
- Drug Implants
(therapeutic use)
- Glucocorticoids
(therapeutic use)
- Humans
- Intravitreal Injections
- Macular Edema
(drug therapy, prevention & control)
- Middle Aged
- Treatment Outcome
- Uveitis
(drug therapy)
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