A genetic variation in CHI3L1 is associated with bronchial asthma.

Abstract

BACKGROUND:

This study was aimed to investigate the associations among Chitinase 3-like 1 (CHI3L1) polymorphisms, asthma and plasma YKL-40 levels in Chinese population.

MATERIAL AND METHODS:

Four CHI3L1 single nucleotide polymorphisms (SNPs) were genotyped. The YKL-40 level in plasma and eosinophil percentage in peripheral blood were quantified.

RESULTS:

A SNP (rs4950928) in the CHI3L1 promoter was associated with elevated plasma YKL-40 levels (p = .02), asthma (p = .042) and lung function (p = .029 to .002) in this Chinese population. Plasma YKL-40 levels were significantly elevated in patients with asthma compared to those in control subjects (p < .05). Plasma YKL-40 levels were significantly correlated with forced expiratory volume per cent (FEV1%) measurements (p < .05). Although plasma YKL-40 levels were decreased after treatment, the correlation with FEV1% still existed.

CONCLUSIONS:

CHI3L1 locus is a risk factor for asthma in Chinese population.

• Authors: Jinlian Shao, Xuexi Yang, Dunqiang Ren, Yaling Luo, Wenyan Lai
• Journal: Archives of physiology and biochemistry (Arch Physiol Biochem) Vol. 127 Issue 3 Pg. 279-284 (Jun 2021) ISSN: 1744-4160 [Electronic] England
• PMID: 31295039 (Publication Type: Journal Article)

Chemical References

• CHI3L1 protein, human
• Chitinase-3-Like Protein 1

Topics

• Adult
• Asthma (blood, genetics)
• Chitinase-3-Like Protein 1 (blood, genetics)
• Female
• Genetic Loci (genetics)
• Genetic Predisposition to Disease (genetics)
• Humans
• Male
• Middle Aged
• Polymorphism, Single Nucleotide
• Promoter Regions, Genetic (genetics)