Abstract | OBJECTIVES: The "nAG" protein is the key protein mediating the regeneration of amputated limbs in salamanders. The senior author (MMA) developed the original hypothesis that since "nAG" is a "regenerative" protein, it must be also an "antifibrotic' protein. The antifibrotic properties were later confirmed in a rabbit skin hypertrophic scar model as well as in a rat spinal cord injury model. The aim of this study is to evaluate the potential therapeutic properties of the nAG protein in a rat liver fibrosis model. METHODOLOGY: RESULTS: The CCL4 treatment resulted in a significant increase in the serum levels of all 6 measured proteins. The nAG treatment significantly reduced these high levels. The degree of liver fibrosis was also significantly reduced in the CCL4/nAG group compared to the CCL4 group. CONCLUSIONS: nAG treatment was able to significantly reduce the serum levels of several protein markers of liver fibrosis and also significantly reduced the histological degree of liver fibrosis.
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Authors | Maha M Arafah, Mohammad M Al-Qattan, Durria A Abdulmaged-Ahmed, Ghada A Al-Nafesah, Nessrin Y Jadu, Reginald S Bagayawa, Medhat K Shier, Amir Marzouk, Hend S Almalki |
Journal | BioMed research international
(Biomed Res Int)
Vol. 2019
Pg. 9846919
( 2019)
ISSN: 2314-6141 [Electronic] United States |
PMID | 31275996
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Recombinant Proteins
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Topics |
- Animals
- Biomarkers
(blood)
- Disease Models, Animal
- Liver Cirrhosis
(blood, drug therapy, pathology)
- Rats, Sprague-Dawley
- Recombinant Proteins
(blood, therapeutic use)
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