Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells under Hypoxia via mir-491.

Abstract

BACKGROUND:

Ginsenoside Rh2 (Rh2), which is extracted from ginseng, exerts antitumor activity. Here we would like to study the role of Rh2 on hypoxia-induced migration in lung adenocarcinoma.

METHODS:

Lung adenocarcinoma A549 and H1299 cells were cultured in 1% O2 condition to mimic the hypoxic tumor microenvironment. The migrations of cancer cells were measured by transwell assay and scratch assay.

RESULTS:

Rh2 could inhibit hypoxia-induced A549 and H1299 cell migration via increase of mir-491 expression. Further, mir-491 antisense oligonucleotide could repress hypoxia-induced migration and the expression of matrix metalloproteinase (MMP)-9 expression in Rh2-treated A549 cells.

CONCLUSION:

These findings suggest that Rh2 exerts anti-metastasis activity in the hypoxic tumor microenvironment in lung adenocarcinoma cells via mir-491.

• Authors: Yingying Chen, Yuqiang Zhang, Wei Song, Ying Zhang, Xiu Dong, Mingqi Tan
• Journal: Anti-cancer agents in medicinal chemistry (Anticancer Agents Med Chem) Vol. 19 Issue 13 Pg. 1633-1641 ( 2019) ISSN: 1875-5992 [Electronic] Netherlands
• PMID: 31272362 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
• Copyright: Copyright© Bentham Science Publishers; For any queries, please email at [email protected].

Chemical References

• Antineoplastic Agents
• Ginsenosides
• MIRN491 microRNA, human
• MicroRNAs
• ginsenoside Rh2
• MMP9 protein, human
• Matrix Metalloproteinase 9

Topics

• A549 Cells
• Antineoplastic Agents (pharmacology)
• Carcinoma, Non-Small-Cell Lung (pathology)
• Cell Hypoxia
• Cell Movement (drug effects)
• Ginsenosides (pharmacology)
• Humans
• Lung Neoplasms (pathology)
• Matrix Metalloproteinase 9 (drug effects)
• MicroRNAs (metabolism)