Because of the
tumor heterogeneity, poor therapeutic outcome is obtained while the conventional treatments, such as surgery,
radiotherapy, or
chemotherapy are utilized alone. Herein, combinational
therapy strategies have been introduced to solve this problem.
Photothermal therapy (PTT) as a non-invasive thermal therapeutic manner has attracting enormous attentions not only for the effective inhibition in primary
tumors, but also for producing
tumor-associated
antigens from ablated
tumor cell residues which exhibit the feasibility to enhance the therapeutic outcome of
immunotherapy. Here, we report the construction and application of Au@Pt-based nanosystem with rationally designed
peptide (LyP-1-PLGVRG-DPPA-1, LMDP) conjugation for
cancer photothermal-
immunotherapy. The obtained Au@Pt-LMDP nanosystem can serve as a
matrix metalloproteinase (
MMP) activated
tumor targeting agents for effective
photothermal therapy together with
immune checkpoint blockade immunotherapy by the on-demand release of a D-
peptide antagonist of programmed cell death-
ligand 1 (PD-L1). The PA imaging demonstrates its effective accumulation in the
tumor region by the activated
tumor targeting moiety derived from the LMDP. Moreover, in vivo anti-
tumor studies reveal that Au@Pt-LMDP nanosystem can effectively eliminate primary
tumors via PTT, and further stimulate the activation of cytotoxic T lymphocytes by PD-L1 immune checkpoint blockage, result in inhibiting the growth of distal
tumors and alleviating
tumor metastasis. The present study provides a promising strategy for the combination treatment of advanced
cancer and obtains a valuable therapeutic outcome in
tumor photothermal-
immunotherapy.