Abstract | BACKGROUND AND AIMS: METHODS AND RESULTS: From January 2014 to December 2017, we consecutively enrolled 804 essential hypertensive patients (407 men and 397 women, mean age 50 ± 14 years) without cardiovascular complications, distinguishing patients in quartiles according to PAC. Compared with the first quartile, the highest PAC quartile was associated with the highest levels of serum uric acid (SUA) (5.3 ± 1.3 vs. 5.0 ± 1.0 mg/dl; P = 0.01), triglycerides (117.5 ± 15.7 vs. 106.8 ± 10.5 mg/dl; P < 0.05), 24-h urinary albumin excretion (UAE) (38.8 ± vs. 7.6 ± mg/24 h; P < 0.05), cIMT (0.87 ± 0.22 vs. 0.80 ± 0.21 mm; P = 0.001) and increased prevalence of carotid plaques (26 vs. 16%; P < 0.005). Moreover, we found that in patients with PAC more than 150 pg/ml, the ABI was significantly lower than those with PAC < 150 pg/ml (1.01 ± 0.09 vs. 1.10 ± 0.09; P < 0.022). PAC was also found to be an independent predictor of the presence of carotid plaques and pathological ABI (<0.9) in essential hypertensive individuals. CONCLUSION: Our results revealed that higher PAC values are strongly associated with some metabolic variables, as triglycerides, UAE, cIMT, worse ABI and major prevalence of carotid plaques that, together with elevated blood pressure values, are strictly correlated with higher risk of atherosclerosis and cardiovascular complications.
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Authors | Antonio Concistrè, Luigi Petramala, Valeria Bisogni, Martina Mezzadri, Federica Olmati, Vincenza Saracino, Gaia Oliviero, Maria Bonvicini, Gianfranco Tonnarini, Gino Iannucci, Claudio Letizia |
Journal | Journal of hypertension
(J Hypertens)
Vol. 37
Issue 11
Pg. 2232-2239
(11 2019)
ISSN: 1473-5598 [Electronic] Netherlands |
PMID | 31205201
(Publication Type: Journal Article)
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Chemical References |
- Biomarkers
- Triglycerides
- Uric Acid
- Aldosterone
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Topics |
- Adult
- Aldosterone
(blood)
- Ankle Brachial Index
- Atherosclerosis
(blood, etiology)
- Biomarkers
(blood)
- Carotid Intima-Media Thickness
- Essential Hypertension
(blood, complications)
- Female
- Humans
- Hypertension
- Male
- Middle Aged
- Triglycerides
(blood)
- Uric Acid
(blood)
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