Mineralocorticoids

A group of CORTICOSTEROIDS primarily associated with water and electrolyte balance. This is accomplished through the effect on ION TRANSPORT in renal tubules, resulting in retention of sodium and loss of potassium. Mineralocorticoid secretion is itself regulated by PLASMA VOLUME, serum potassium, and ANGIOTENSIN II.

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Networked: 2053 relevant articles (44 outcomes, 151 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Experts

1.	Lang, Florian: 19 articles (01/2020 - 08/2005)
2.	New, Maria I: 11 articles (12/2018 - 07/2002)
3.	Zennaro, Maria-Christina: 11 articles (07/2017 - 06/2003)
4.	Stewart, Paul M: 10 articles (10/2014 - 06/2003)
5.	Charmandari, Evangelia: 10 articles (06/2014 - 05/2002)
6.	Arlt, Wiebke: 9 articles (10/2021 - 05/2003)
7.	Young, Morag J: 9 articles (01/2021 - 12/2006)
8.	Chrousos, George P: 9 articles (06/2014 - 04/2002)
9.	Odermatt, Alex: 8 articles (01/2021 - 04/2007)
10.	Quinkler, Marcus: 8 articles (01/2020 - 06/2003)

Related Diseases

1.	Hypertension (High Blood Pressure) 10/01/2016 - "Protective effects of MCR-1329, a dual α1 and angII receptor antagonist, in mineralocorticoid-induced hypertension." 01/01/2007 - "This study examines whether mineralocorticoid antagonism ameliorates or prevents the adverse cardiac effects of hypertension and aging. " 11/01/2002 - "Results of this study indicate that obese Zucker rats are more sensitive to mineralocorticoid-induced hypertension than lean rats. " 07/01/1997 - "The aim of the study was to evaluate if short-term mineralocorticoid administration activates the circulating kallikrein-kinin systems in normotensive humans and patients with hypertension. " 01/01/1996 - "Thus the study of mineralocorticoid biosynthesis and action remains one of the most promising approaches to understanding hypertension."
2.	Adrenal Insufficiency (Adrenal Gland Hypofunction) 05/01/2011 - "The finding of a normal leukogram (absence of a stress leukogram) can be indicative of adrenal insufficiency in dogs, and this disorder can be especially elusive when there are no overt indicators of mineralocorticoid deficiency. " 01/01/1998 - "Adrenal insufficiency is well controlled by gluco- and mineralocorticoids. " 02/24/1997 - "Acute adrenal insufficiency is primarily a state of mineralocorticoid deficiency. " 01/01/1983 - "It is being suggested that the changes of PRC, RRA and RSC observed up to the 10th post-enucleation day indicates relative adrenal insufficiency, the shorter duration of which in immature rats reflects their higher sensitivity to mineralocorticoids produced by the regenerating adrenal. " 01/01/2011 - "Replacement therapy with gluco-and mineralocorticoids is life-saving for patients with chronic adrenal insufficiency."
3.	Hyperkalemia 10/17/2023 - "Current CKD treatments primarily involve renin-angiotensin-aldosterone system inhibitors and mineralocorticoid receptor antagonists, albeit associated with hyperkalemia risks. " 01/01/2022 - "We speculated that severe mineralocorticoid resistance was the reason why her hyperkalemia persisted even with 0.4 mg/d of FC; however, the pathophysiology of transiently severe resistance to FC in this patient is unknown. " 10/01/2019 - "Mineralocorticoids as a Treatment for Selected Cases of Refractory Hyperkalemia." 02/01/1988 - "Renal mineralocorticoid resistance has been suggested to account for the hyperkalemia in SLE. " 05/01/1977 - "Mineralocorticoid administration corrected the hyperkalemia. "
4.	Septic Shock (Toxic Shock Syndrome) 09/01/2021 - "Few providers are using adjunctive mineralocorticoids in septic shock, although recent level 1 evidence have shown a survival benefit. " 08/01/2010 - "At doses used in septic shock, HC induced greater mineralocorticoid effect than FC did. " 10/01/2019 - "Combination of low-dose glucocorticosteroids and mineralocorticoids as adjunct therapy for adult patients with septic shock: A systematic review and meta-analysis of randomized trials and observational studies." 01/01/2012 - "Efficacy of selective mineralocorticoid and glucocorticoid agonists in canine septic shock." 09/01/2017 - "We aimed to study the effects of mineralocorticoids and the involvement of vascular mineralocorticoid receptors in murine endotoxic and human septic shock. "
5.	Addison Disease (Addison's Disease) 08/01/2013 - "There is evidence suggesting that autoimmune Addison's disease (AD) could be associated with sexual dysfunctions probably caused by gluco- and mineralocorticoid deficiency; however, no study has yet treated this subject in males. " 11/01/2023 - "Addison's disease (AD) entails a chronic insufficient production of gluco- and mineralocorticoids. " 01/01/2023 - "Heterogeneous natural history of Addison's disease: mineralocorticoid deficiency may predominate." 02/01/2018 - "Mineralocorticoid replacement is often necessary for primary adrenal insufficiency but not for corticotroph deficiency. " 06/01/2017 - "Patients with primary adrenal insufficiency also require mineralocorticoid. "

Related Drugs and Biologics

1.	Glucocorticoids
2.	Aldosterone
3.	Sodium
4.	Salts
5.	Renin
6.	Steroids
7.	Eplerenone (Inspra)
8.	Captopril (Capoten)
9.	Fludrocortisone
10.	Dexamethasone (Maxidex)

Related Therapies and Procedures

1.	Therapeutics
2.	Castration
3.	Drug Therapy (Chemotherapy)
4.	Kidney Transplantation
5.	Adrenalectomy