Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease.

Abstract	We report orobol as a multifunctional isoflavone with the ability to (i) modulate the aggregation pathways of both metal-free and metal-bound amyloid-β, (ii) interact with metal ions, (iii) scavenge free radicals, and (iv) inhibit the activity of acetylcholinesterase. Such a framework with multifunctionality could be useful for developing chemical reagents to advance our understanding of multifaceted pathologies of neurodegenerative disorders, including Alzheimer's disease.
Authors	Geewoo Nam, Yonghwan Ji, Hyuck Jin Lee, Juhye Kang, Yelim Yi, Mingeun Kim, Yuxi Lin, Young-Ho Lee, Mi Hee Lim
Journal	ACS chemical neuroscience (ACS Chem Neurosci) Vol. 10 Issue 8 Pg. 3386-3390 (08 21 2019) ISSN: 1948-7193 [Electronic] United States
PMID	31199606 (Publication Type: Journal Article, Research Support, Non-U.S. Gov't)
Chemical References	Amyloid beta-Peptides Enzyme Inhibitors Flavonoids Free Radical Scavengers Acetylcholinesterase orobol
Topics	Acetylcholinesterase (drug effects) Alzheimer Disease (pathology) Amyloid beta-Peptides (chemistry, drug effects) Animals Enzyme Inhibitors (pharmacology) Flavonoids (chemistry, pharmacology) Free Radical Scavengers (pharmacology) Humans Protein Aggregation, Pathological (drug therapy)

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