orobol

from Aspergillus niger or Streptomyces neyagawaensis; potent inhibitor of phosphatidylinositol kinase

Also Known As:

3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-4H-1-benzopyran-4-one; isoluteolin; 4H-1-Benzopyran-4-one, 3-(3,4-dihydroxyphenyl)-5,7-dihydroxy-

Networked: 10 relevant articles (1 outcomes, 1 trials/studies)

Relationship Network

Bio-Agent Context: Research Results

Heterocyclic Compounds: 198
- 1-Ring Heterocyclic Compounds
  - Pyrans: 130
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        orobol: 10
- Fused-Ring Heterocyclic Compounds
  - 2-Ring Heterocyclic Compounds
    - Benzopyrans: 195
      - Chromones: 159
        Flavonoids: 9773
        orobol: 10

Experts

1.	Kim, Jong-Eun: 3 articles (04/2022 - 01/2019)
2.	Lee, Ki Won: 3 articles (04/2022 - 01/2019)
3.	Yang, Hee: 3 articles (04/2022 - 01/2019)
4.	Kim, Jong Hun: 2 articles (09/2020 - 01/2019)
5.	Park, Jung Han Yoon: 2 articles (09/2020 - 01/2019)
6.	Ji, Yonghwan: 2 articles (01/2020 - 01/2019)
7.	Kang, Juhye: 2 articles (01/2020 - 01/2019)
8.	Kim, Mingeun: 2 articles (01/2020 - 01/2019)
9.	Lee, Hyuck Jin: 2 articles (01/2020 - 01/2019)
10.	Lee, Young-Ho: 2 articles (01/2020 - 01/2019)

Related Diseases

1.	Neoplasms (Cancer) 01/01/2023 - "In the mouse model with intermittent dosing of orobol, our data showed that re-application of orobol is effective for reducing tumor regrowth after discontinuation of treatment. " 01/01/2023 - "Furthermore, orobol showed therapeutic efficacy after the formation of chronic SSL irradiation-induced tumor. "
2.	Hypersensitivity (Allergy) 04/20/2022 - "Furthermore, a few studies have demonstrated that orobol decreases pro-inflammatory compounds resulting in the alleviation of allergic reactions. "
3.	Carcinoma (Carcinomatosis) 07/01/2007 - "Orobol enhanced PX sensitivity of human ovarian carcinoma 2008 cells by 18.9+/-1.2-fold (N=3; P<0.01). " 08/01/2003 - "These results indicate that orobol produced DDP sensitivity in human ovarian carcinoma cells by inducing apoptosis through the MT-dependent signaling pathway." 08/01/2003 - "Orobol produced >2-fold DDP sensitivity in human ovarian carcinoma 2008 cells and its DDP-resistant variant 2008/C13*5.25 cells (C13). " 02/01/2001 - "Clonogenic survival assay was used to determine the effect of orobol, a potent PI4-kinase inhibitor, on DDP sensitivity in human ovarian carcinoma 2008 cells. " 02/01/2001 - "Differential sensitization by orobol in proliferating and quiescent human ovarian carcinoma cells."
4.	Alzheimer Disease (Alzheimer's Disease) 01/01/2020 - "Correction to "Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease"." 01/01/2019 - "Orobol: An Isoflavone Exhibiting Regulatory Multifunctionality against Four Pathological Features of Alzheimer's Disease."
5.	Carcinogenesis 03/09/2004 - "To clarify the molecular mechanisms underlying the induction of carcinogenesis by soy isoflavones, we examined the ability of genistein, daidzein, and their metabolites, 5,7,3',4'-tetrahydroxyisoflavone (orobol), 7,3',4'-trihydroxyisoflavone (7,3',4'-OH-IF), and 6,7,4'-trihydroxyisoflavone (6,7,4'-OH-IF), to cause DNA damage and cell proliferation. "

Related Drugs and Biologics

1.	Genistein
2.	Isoflavones
3.	Enzymes
4.	Casein Kinase 1 epsilon
5.	Cytochromes c (Cytochrome c)
6.	Paclitaxel (Taxol)
7.	Platelet-Derived Growth Factor
8.	Lipids
9.	Cisplatin (Platino)
10.	6,7,4'-trihydroxyisoflavone