Serum apolipoprotein C3 levels are negatively associated with hepatitis B virus DNA in HBeAg-negative chronic hepatitis B patients.

Abstract

BACKGROUND:

Hepatitis B virus (HBV) infection remains a global health issue associated with substantial morbidity and mortality. Serum apolipoprotein C3 (ApoC3) and apolipoprotein A5 (ApoA5) levels were decreased in chronic hepatitis B (CHB) patients, however the relationship between ApoC3 or ApoA5 and HBV DNA load remains elusive.

METHODS:

A total of 384 CHB patients including 194 HBsAg(+) HBeAg(-) and 190 HBsAg(+) HBeAg(+) and 154 healthy individuals were recruited in our study. Serum levels of alanine aminotransferase (ALT), aspartate transaminase (AST), total cholesterol (Chol), triglycerides (TG), apolipoprotein A1 (ApoA1), apolipoprotein B (ApoB), high-density lipoproteins cholesterol (HDL-C), low-density lipoproteins cholesterol (LDL-C) and lipoprotein a (Lpa) were examined in an automatic biochemical analyzer. Apolipoprotein A5 (ApoA5) and apolipoprotein C3 (ApoC3) were detected via ELISA.

RESULTS:

Serum ApoA1, ApoB, ApoC3 and ApoA5 levels were reduced in CHB patients. In HBeAg(-) CHB patients, plasma ApoC3 levels were negatively associated with HBV DNA load (r = 0.219, P < 0.001). But no correlation between ApoA5 and HBV DNA load was observed in CHB patients.

CONCLUSIONS:

These data showed that HBV infection inhibits lipid metabolism and ApoC3 is negatively associated with HBV DNA load in HBeAg (-) CHB patients. These findings provided new evidence about the link between ApoC3-related lipid metabolism and immune response.

• Authors: Yu Cui, Xiang-Dan Cui, Meng Xu, Min Fang, Mei-Juan Cai
• Journal: Lipids in health and disease (Lipids Health Dis) Vol. 18 Issue 1 Pg. 138 (Jun 11 2019) ISSN: 1476-511X [Electronic] England
• PMID: 31186008 (Publication Type: Journal Article)

Chemical References

• APOA5 protein, human
• APOC3 protein, human
• Apolipoprotein A-V
• Apolipoprotein C-III
• Apolipoproteins B
• Cholesterol, HDL
• Cholesterol, LDL
• DNA, Viral
• Hepatitis B e Antigens
• Triglycerides

Topics

• Adult
• Apolipoprotein A-V (blood)
• Apolipoprotein C-III
• Apolipoproteins B (blood)
• Cholesterol, HDL (blood)
• Cholesterol, LDL (blood)
• DNA, Viral (genetics)
• Enzyme-Linked Immunosorbent Assay
• Female
• Hepatitis B e Antigens (genetics)
• Hepatitis B virus (genetics)
• Hepatitis B, Chronic (blood, virology)
• Humans
• Male
• Middle Aged
• Triglycerides (blood)