Abstract | BACKGROUND: METHODS: RESULTS: Compared with before treatment (baseline), the aqueous flare value showed a significant decrease at both 1 month and 6 months after IRI therapy. There were significant correlations between the aqueous flare value and the aqueous levels of sVEGFR-1, placental growth factor, monocyte chemoattractant protein 1, soluble intercellular adhesion molecule-1, interleukin (IL)-6, and IL-8. In addition, a significant correlation was noted between the change of the aqueous flare value and improvement of central macular thickness at 6 months after IRI, as well as a significant correlation between the change of the aqueous flare value and improvement of best-corrected visual acuity at 6 months. CONCLUSIONS: These findings suggest that IRI reduces inflammation and that the aqueous flare value is influenced by inflammatory factors/ cytokines. In addition, the change of the aqueous flare value may be an indicator of the long-term prognosis in CRVO patients receiving IRI therapy for macular edema.
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Authors | Asako Mashima, Hidetaka Noma, Kanako Yasuda, Hiroshi Goto, Masahiko Shimura |
Journal | Journal of inflammation (London, England)
(J Inflamm (Lond))
Vol. 16
Pg. 9
( 2019)
ISSN: 1476-9255 [Print] England |
PMID | 31139023
(Publication Type: Journal Article)
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