Clinical value of significance of Hypoxia Inducible Factor-1α, Glucose Transporter-1 and Carbonic Anhydrase IX in rectal cancer after preoperative chemoradiotherapy.

Abstract

PURPOSE:

The standard treatment of rectal cancer is surgery along with preoperative radiotherapy, administered alone or in combination with chemotherapy. Preoperative chemoradiotherapy (preCRT) is widely used as it allows better local control and the use of sphincter-saving surgery. Pathological response after preCRT has been shown to be a significant prognostic factor of rectal cancer recurrence and survival. In this review we will assess the value of Hypoxia Induced Factor 1α (HIF-1α), Carbonic Anhydrase IX (CA-9) and Glucose Transporter 1 (GLUT-1) genes as predictive markers of the course of local advanced rectal cancer in patients who underwent pre-CRT.

METHODS:

We searched studies, from Pubmed and in English language, obtained the information by using "HIF-1 alpha", "Carbonic Anhydrase IX (CA-9)", "Glucose Transporter 1 (GLUT-1)" and "rectal cancer" as key words.

RESULTS:

27 relevant articles were retrieved in initial stage. After full-text review, 13 articles were selected for the final analysis.

CONCLUSIONS:

HIF-1α, GLUT-1 and CA-IX may be connected with tumor response to preCRT, however, there is still skepticism towards their clinical use as predictors of outcome. Therefore, there is a need to conduct larger and more extensive cohort studies in order to find whether these predictors can be used in practice.

• Authors: Dimitra-Irinna Vitoratou, Maria Tolia, Panagiotis Liakos, Nikolaos Tsoukalas, Constantinos Giaginis, Michail Nikolaou, Georgios Nikolaou, Georgios Rigas, Kyriakos Psarianos, Athanassios Lioupis, George Kyrgias
• Journal: Journal of B.U.ON. : official journal of the Balkan Union of Oncology (J BUON) 2019 Mar-Apr Vol. 24 Issue 2 Pg. 456-463 ISSN: 2241-6293 [Electronic] Cyprus
• PMID: 31127991 (Publication Type: Journal Article, Meta-Analysis)

Chemical References

• Antigens, Neoplasm
• Biomarkers, Tumor
• Glucose Transporter Type 1
• HIF1A protein, human
• Hypoxia-Inducible Factor 1, alpha Subunit
• CA9 protein, human
• Carbonic Anhydrase IX

Topics

• Antigens, Neoplasm (genetics)
• Biomarkers, Tumor (genetics)
• Carbonic Anhydrase IX (genetics)
• Chemoradiotherapy (methods)
• Female
• Gene Expression Regulation, Neoplastic (drug effects, radiation effects)
• Glucose Transporter Type 1 (genetics)
• Humans
• Hypoxia-Inducible Factor 1, alpha Subunit (genetics)
• Male
• Neoplasm Recurrence, Local (epidemiology, genetics)
• Preoperative Period
• Rectal Neoplasms (drug therapy, epidemiology, genetics, radiotherapy)