Abstract | BACKGROUND: METHODS: Between Jan. 2004 and Dec. 2015, stage pIII-N2 NSCLC patients receiving pneumonectomy and adjuvant chemotherapy with or without PORT in our institution were retrospectively reviewed. RESULTS: Totally 119 patients were included, 32 patients receiving adjuvant chemotherapy and PORT (PORT group) and 87 receiving adjuvant chemotherapy alone (Control group). There were more patients with non-R0 resection in PORT group than Control group (25% vs. 8%, p = 0.031). In PORT group, ≥Grade 2 radiation-induced pneumonitis was 2/32. No severe radiation-related heart injury was observed. There was no PORT-related death. Of all patients, median follow-up time was 25 months. Median overall survival time (mOS) and median disease-free survival time (mDFS) were 46 months and 15 months, respectively. The PORT group had significantly better OS (not reached vs. 34 months, p = 0.003), DFS (19 months vs. 13 months, p = 0.024), local recurrence free survival (LRFS, p = 0.012), and distant metastasis free survival (DMFS, p = 0.047) than the Control group. As for failure pattern, PORT significantly reduced local regional failure rate (39.1% vs. 15.6%, p = 0.016). In subgroup analysis, patients with R0 resection (n = 104), OS and LRFS in PORT group were significantly longer, and PORT tended to increase DFS and DMFS. CONCLUSION:
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Authors | Wenhui Wang, Yu Men, Jianyang Wang, Zongmei Zhou, Dongfu Chen, Zefen Xiao, Qinfu Feng, Jima Lv, Jun Liang, Nan Bi, Shugeng Gao, Luhua Wang, Zhouguang Hui |
Journal | BMC cancer
(BMC Cancer)
Vol. 19
Issue 1
Pg. 478
(May 22 2019)
ISSN: 1471-2407 [Electronic] England |
PMID | 31113432
(Publication Type: Comparative Study, Journal Article)
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Topics |
- Adult
- Aged
- Carcinoma, Non-Small-Cell Lung
(pathology, therapy)
- Chemotherapy, Adjuvant
- Female
- Humans
- Lung Neoplasms
(pathology, therapy)
- Lymph Node Excision
- Male
- Mediastinum
(surgery)
- Middle Aged
- Neoplasm Staging
- Pneumonectomy
- Radiotherapy, Adjuvant
- Retrospective Studies
- Survival Analysis
- Treatment Outcome
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