p53 and β-Catenin Expression Predict Poorer Prognosis in Patients With Anaplastic Large-Cell Lymphoma.

Abstract

BACKGROUND:

The Wnt/β-catenin signaling pathway is a major target of p53. β-Catenin/p53 coexpression predicts poorer survival in carcinoma patients. Conversely, CD99 inhibits tumor metastasis through the Wnt/β-catenin pathway. We therefore assessed p53, β-catenin, and CD99 by immunohistochemistry.

PATIENTS AND METHODS:

We studied 45 patients with systemic anaplastic large-cell lymphoma (ALCL), including 20 anaplastic lymphoma kinase (ALK)-positive and 25 ALK-negative ALCL. β-Catenin expression was analyzed using phospho-β-catenin-S552 antibody because its nuclear localization indicates Wnt signaling.

RESULTS:

In this cohort, p53 expression was associated with ALK-negative ALCL. Furthermore, p53 or β-catenin expression alone or β-catenin/p53 double expression showed poorer overall survival and disease-free survival in patients with ALCL overall and in patients with ALK-negative ALCL. CD99 expression was more frequent in ALK-positive ALCL but had no prognostic significance.

CONCLUSION:

This is the first study to evaluate phospho-β-catenin-S552 expression in ALCL. The results of this study, although limited by small patient size, suggest that β-catenin and p53 may play a role in pathogenesis and may be helpful in risk stratification of ALCL patients.

• Authors: Aida Ibricevic Richardson, C Cameron Yin, Wei Cui, Nianyi Li, L Jeffrey Medeiros, Linheng Li, Da Zhang
• Journal: Clinical lymphoma, myeloma & leukemia (Clin Lymphoma Myeloma Leuk) Vol. 19 Issue 7 Pg. e385-e392 (07 2019) ISSN: 2152-2669 [Electronic] United States
• PMID: 31078446 (Publication Type: Journal Article)
• Copyright: Copyright © 2019 Elsevier Inc. All rights reserved.

Chemical References

• Tumor Suppressor Protein p53
• beta Catenin
• ALK protein, human
• Anaplastic Lymphoma Kinase

Topics

• Adolescent
• Adult
• Aged
• Anaplastic Lymphoma Kinase (genetics, metabolism)
• Female
• Gene Expression
• Humans
• Immunohistochemistry
• Lymphoma, Large-Cell, Anaplastic (genetics, metabolism, mortality, pathology)
• Male
• Middle Aged
• Prognosis
• Recurrence
• Tumor Suppressor Protein p53 (genetics)
• Young Adult
• beta Catenin (genetics)