Abstract | BACKGROUND AND OBJECTIVE: METHODS: We enrolled 13 patients from an initial cohort of adult patients with IgE-mediated wheat allergy (mean age, 40 years). After diagnosis, the patients observed a wheat-free diet and were followed as outpatients for 5 years to evaluate wheat exposure. Wheat-IgEtiters were determined at the end of follow-up, and a second wheat-challenge was performed. RESULTS: Ten out of 13 patients took part in the study. The mean period of wheat avoidance was 4.2 years. Three patients had spontaneously reintroduced wheat before the second evaluation, after a mean (IQR) of 28 (18-36) months, with only mild gastrointestinal discomfort at reintroduction. At the end of follow-up, 9 of the 10 patients were wheat-tolerant. Two patients had a history of WDEIA. We observed a reduction in IgE levels, with median (IQR) IgE falling from 2.77 (0.35-100) kU/L at diagnosis to 0.88 (0.1-20.8) kU/L. The association between IgE and a negative challenge result was not statistically significant. CONCLUSION:
IgE-mediated wheat allergy in adults is benign and represents a temporary break in gastrointestinal tolerance. Future studies may improve our knowledge of wheat allergens, routes of and factors leading to sensitization, and prognostic biomarkers.
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Authors | J Scibilia, M Rossi Carlo, M Losappio Laura, C Mirone, L Farioli, V Pravettoni, E A Pastorello |
Journal | Journal of investigational allergology & clinical immunology
(J Investig Allergol Clin Immunol)
Vol. 29
Issue 2
Pg. 118-123
(Apr 2019)
ISSN: 1018-9068 [Print] Spain |
PMID | 31017108
(Publication Type: Journal Article)
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Chemical References |
- Allergens
- Immunoglobulin E
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Topics |
- Adolescent
- Adult
- Allergens
(immunology)
- Cross Reactions
(immunology)
- Female
- Follow-Up Studies
- Humans
- Immunoglobulin E
(immunology)
- Male
- Middle Aged
- Patient Outcome Assessment
- Prognosis
- Skin Tests
- Triticum
(adverse effects)
- Wheat Hypersensitivity
(diagnosis, epidemiology, immunology)
- Young Adult
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