Circulating neuromedin U levels are similar in subjects with NGT and newly diagnosed T2DM and do not correlate with insulin secretion.

Abstract

AIMS:

Neuromedin U (NMU), a highly conserved peptide, is implicated in energy homeostasis and is involved in regulating insulin secretion as a decretin hormone in animals. However, there have been no reports on the relationship between NMU and type 2 diabetes mellitus (T2DM). The aim of this study was to investigate circulating NMU concentrations in healthy subjects and T2DM patients and to evaluate the association between serum NMU levels and glucose-stimulated insulin secretion.

METHODS:

We used ELISA to analyze NMU concentrations in blood samples from newly diagnosed T2DM patients (n = 57) and age-, sex- and BMI-matched healthy control subjects (n = 50). Anthropometric parameters, oral glucose tolerance, glycosylated hemoglobin, blood lipids, insulin sensitivity, and insulin secretion were measured.

RESULTS:

No difference was observed in serum NMU levels between control subjects and newly diagnosed T2DM patients (p = 0.788). The oral glucose tolerance test (OGTT) results indicated that serum NMU concentrations did not change and did not correlate with insulin levels at fasting and 1 h, 2 h and 3 h after glucose load in both healthy controls and newly diagnosed T2DM patients.

CONCLUSION:

Circulating NMU concentrations were similar in control subjects and newly diagnosed T2DM patients and were not associated with glucose-stimulated insulin secretion. Serum NMU is not a human decretin hormone and may not play a role in the pathogenesis of T2DM.

• Authors: Mingzhu Han, Yanhong Xu, Jing Yuan, Yi Zhu, Jianhua Zhou, Lu Liu, Xiaohua Li, Hongli Zhang
• Journal: Diabetes research and clinical practice (Diabetes Res Clin Pract) Vol. 151 Pg. 163-168 (May 2019) ISSN: 1872-8227 [Electronic] Ireland
• PMID: 31004673 (Publication Type: Journal Article)
• Copyright: Copyright © 2019. Published by Elsevier B.V.

Chemical References

• Blood Glucose
• Neuropeptides
• neuromedin U

Topics

• Blood Glucose (analysis)
• Diabetes Mellitus, Type 2 (blood, physiopathology)
• Female
• Humans
• Insulin Secretion (physiology)
• Male
• Middle Aged
• Neuropeptides (metabolism)