Abstract | AIM: to evaluate antioxidant properties of dietary supplements Nefradoz, as well as its role in the prevention of calcium oxalate stones. MATERIALS AND METHODS: Our study consisted of two parts, clinical and experimental. In the clinical trial a total of 80 patients with recurrent calcium oxalate urolithiasis of various localization were included. All patients were divided into 2 groups. In treatment group (n=45) patients received Nefradoz 1 capsule 2 times a day. In control group (n=35) no treatment was prescribed. In all patients a biomarkers level (bikunin, osteopontin, nephrocalcin) in urine was determined by ELISA. In addition, Litos-test was performed. Follow-up duration was 6 months. In the experimental part of the study, the antioxidant properties of Nefradoz were evaluated using chemiluminescence method. RESULTS: The antioxidant activity of resveratrol, which is contained in 300 mg Nefradoz (1 capsule), was 23.66+/-1.18, which corresponds to the moderate activity. After 6 months of therapy a level of bikunin and osteopontin did not significantly changed, which indicates a minimal risk of stone recurrence. According to the Litos-test, the activity of stone formation in Nefradoz group significantly decreased to minimal values in 42 out 45 patients (p<0.05). In the control group an excretion of biomarkers was minimal, which significantly increased the risk of stone formation. CONCLUSION:
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Authors | A A Kamalov, D A Okhobotov, E V Proskurnina, M M Sozarukova, A N Nizov |
Journal | Urologiia (Moscow, Russia : 1999)
(Urologiia)
Issue 6
Pg. 52-59
(Dec 2018)
ISSN: 1728-2985 [Print] Russia (Federation) |
PMID | 30742378
(Publication Type: Journal Article)
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Chemical References |
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Topics |
- Calcium
- Calcium Oxalate
- Dietary Supplements
- Humans
- Nephrolithiasis
- Recurrence
- Urinary Calculi
- Urolithiasis
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