Abstract | BACKGROUND: METHODS: The wall area (WA) and airway inner luminal area (Ai) of third-to sixth-generation bronchi and the percentage of low attenuation area with less than -950 HU (%LAA) of the lungs were measured using three-dimensional computed tomography in patients with COPD. WA and Ai were corrected by body surface area (BSA). RESULTS: Forty-two clinically stable patients with COPD were enrolled. The median (range) mMRC dyspnea scale was 2 (0-3). The mMRC dyspnea scale score was significantly correlated with WA/BSA of fifth- and sixth-generation bronchi (Spearman correlation coefficient ρ = 0.386, p = 0.012; ρ = 0.484, p = 0.001, respectively). Partial rank correlation analysis showed that the mMRC dyspnea scale score was significantly correlated with WA/BSA of sixth-generation bronchi, independent of the confounding factors of age, body mass index, %predicted forced expiratory volume in 1 s, %LAA, and Ai/BSA (ρ = 0.481, p = 0.003). However, the %LAA and Ai/BSA were not correlated with this dyspnea scale. CONCLUSION: Bronchial WA assessed by three-dimensional computed tomography may be used as an assessment tool for dyspnea in patients with COPD.
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Authors | Hideki Yasui, Naoki Inui, Masato Karayama, Kazutaka Mori, Hironao Hozumi, Yuzo Suzuki, Kazuki Furuhashi, Noriyuki Enomoto, Tomoyuki Fujisawa, Yutaro Nakamura, Hiroshi Watanabe, Takafumi Suda |
Journal | Respiratory medicine
(Respir Med)
Vol. 146
Pg. 76-80
(01 2019)
ISSN: 1532-3064 [Electronic] England |
PMID | 30665522
(Publication Type: Journal Article)
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Copyright | Copyright © 2018 Elsevier Ltd. All rights reserved. |
Topics |
- Aged
- Aged, 80 and over
- Dyspnea
(diagnostic imaging, physiopathology)
- Female
- Forced Expiratory Volume
- Humans
- Male
- Middle Aged
- Multidetector Computed Tomography
- Pulmonary Disease, Chronic Obstructive
(diagnostic imaging, physiopathology)
- Respiratory Function Tests
- Severity of Illness Index
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