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An extranodal histopathological analysis of idiopathic multicentric Castleman disease with and without TAFRO syndrome.

Abstract
Thrombocytopenia, anasarca, fever, renal failure or reticulin fibrosis, and organomegaly (TAFRO) syndrome, a poor prognostic clinical condition showing similar histopathological findings to idiopathic multicentric Castleman disease (iMCD), has been reported in Japan. In our previous report, a clinicopathological analysis was performed on 70 nodal cases of iMCD with/without TAFRO. iMCD is classified into three types based on histopathology: (i) plasmacytic (PC), (ii) mixed, and (iii) hypervascular (hyperV). In this report, extranodal histopathological changes of iMCD with/without TAFRO were analyzed. Regarding the kidney pathology, we observed the proliferation of mesangial cells with positive staining of interleukin-6 (IL-6), consistent with membranoproliferative glomerulonephritis, in two cases of iMCD with TAFRO. The number of megakaryocytes per high-powered fields was not significantly different between iMCD cases with and without TAFRO. In conclusion, extranodal lesions of iMCD with/without TAFRO showed various interesting histopathological findings. These lesions may therefore be related to the clinical condition of TAFRO. Obtaining further knowledge about TAFRO will require the observation of nodal as well as extranodal lesions.
AuthorsNozomu Kurose, Ken-Ichi Mizutani, Motona Kumagai, Akihiro Shioya, Xin Guo, Satoko Nakada, Shino Fujimoto, Hiroshi Kawabata, Yasufumi Masaki, Kazue Takai, Sadao Aoki, Masaru Kojima, Shigeo Nakamura, Masatoshi Kida, Sohsuke Yamada
JournalPathology, research and practice (Pathol Res Pract) Vol. 215 Issue 3 Pg. 410-413 (Mar 2019) ISSN: 1618-0631 [Electronic] Germany
PMID30642741 (Publication Type: Journal Article, Review)
CopyrightCopyright © 2018 The Authors. Published by Elsevier GmbH.. All rights reserved.
Chemical References
  • Reticulin
Topics
  • Bone Marrow (pathology)
  • Castleman Disease (complications, pathology)
  • Edema (complications)
  • Fever (complications)
  • Fibrosis (complications)
  • Humans
  • Kidney (pathology)
  • Lung (pathology)
  • Renal Insufficiency (complications)
  • Reticulin
  • Skin (pathology)
  • Syndrome
  • Thrombocytopenia (complications)
  • Thymus Gland (pathology)

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