Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)

796  relevant articles (36 outcomes, 67 trials/studies) found for this Disease

Membranoproliferative Glomerulonephritis, Type II; Dense Deposit Disease; Mesangiocapillary Glomerulonephritis; Glomerulonephritis, Membranoproliferative; Glomerulonephritis, Hypocomplementemic; Membranoproliferative Glomerulonephritis, Type I; Membranoproliferative Glomerulonephritis, Type III; Mesangiocapillary Glomerulonephritis, Type I; Mesangiocapillary Glomerulonephritis, Type II; Subendothelial Membranoproliferative Glomerulonephritis; Glomerulonephritides, Hypocomplementemic; Glomerulonephritides, Membranoproliferative; Glomerulonephritides, Mesangiocapillary; Hypocomplementemic Glomerulonephritides; Hypocomplementemic Glomerulonephritis; Membranoproliferative Glomerulonephritides; Membranoproliferative Glomerulonephritis, Subendothelial; Mesangiocapillary Glomerulonephritides; Glomerulonephritis, Mesangiocapillary; MPGN

Relationship Network

Disease Context: Research Results

Related Diseases

1.	Nephrotic Syndrome (Syndrome, Nephrotic)
2.	Membranoproliferative Glomerulonephritis (Membranoproliferative Glomerulonephritis, Type II)
3.	Proteinuria
4.	Infection
5.	Chronic Kidney Failure (Chronic Renal Failure)

Experts

1.	Alpers, Charles E: 4 articles (02/2008 - 09/2003)
2.	Mühlfeld, Anja S: 3 articles (02/2008 - 09/2003)
3.	Butani, Lavjay: 2 articles (06/2008 - 10/2007)
4.	Walport, Mark J: 2 articles (02/2008 - 08/2002)
5.	Bygrave, Anne E: 2 articles (02/2008 - 08/2002)
6.	Pickering, Matthew C: 2 articles (02/2008 - 08/2002)
7.	Hudkins, Kelly L: 2 articles (02/2008 - 12/2007)
8.	Cook, H Terence: 2 articles (02/2008 - 08/2002)
9.	Botto, Marina: 2 articles (02/2008 - 08/2002)
10.	Kowalewska, Jolanta: 2 articles (02/2008 - 12/2007)

Drugs and Biologics

Drugs and Important Biological Agents (IBA) related to Membranoproliferative Glomerulonephritis:

1.	Prednisone (Sone)FDA LinkGeneric 12/01/1999 - "Whereas the outcome of patients with type I MPGN treated with alternate-day prednisone was generally good, similarly treated patients with type III experienced significant reductions in renal function, slower improvement in serum C3 levels, more persistent urinary abnormalities, and more frequent relapses." 03/01/1992 - "It has been claimed that long-term prednisone treatment ameliorates the course of children with mesangiocapillary glomerulonephritis (MCGN)" 03/01/1980 - "Membranoproliferative glomerulonephritis: improved survival with alternate day prednisone therapy." 12/01/1999 - "Differences between membranoproliferative glomerulonephritis types I and III in long-term response to an alternate-day prednisone regimen." 11/01/1985 - "Experience in 45 children with diffuse proliferative MPGN of all three types has provided evidence that a high-dose, alternate-day regimen of prednisone alters the natural history of the disease" Order ALL the reference details at left...
2.	SteroidsIBA 02/01/2006 - "Long-term follow-up of atypical membranoproliferative glomerulonephritis: are steroids indicated?" 01/01/2005 - "The renal biopsy demonstrated pathological findings characteristic of membranoproliferative glomerulonephritis type II. The child was treated with an antihypertensive agent and steroids" 11/01/1999 - "Steroids did not appear to benefit the outcome in types I and III MPGN patients compared to patients who received antihypertensive and antiplatelet treatment without steroids." 04/01/1995 - "The current common practice of treating all children with MPGN with steroids should be re-examined." 04/01/1995 - "Non-nephrotic children with membranoproliferative glomerulonephritis: are steroids indicated?" Order ALL the reference details at left...
3.	Interferon-alpha (Interferon Alfa)FDA Link 01/01/2003 - "Interferon-alpha (IFN-alpha) may precipitate or exacerbate the occurrence of MPGN" 05/01/2001 - "A case of cryoglobulinemic membranoproliferative glomerulonephritis associated with chronic hepatitis C which was effectively treated by interferon alpha-2b]" 07/01/1997 - "Response to high-dose interferon-alpha after failure of standard therapy in MPGN associated with hepatitis C virus infection." 03/01/1996 - "Membranoproliferative glomerulonephritis and hepatitis C: effects of interferon-alpha therapy on clinical outcome and histological pattern." 03/01/1996 - "Effect of human leukocyte alpha interferon on cryoglobulinaemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection." Order ALL the reference details at left...
4.	Complement System Proteins (Complement)IBA 05/01/1999 - "Detailed family studies failed to reveal any evidence of complement deficiencies or secondary cause of MPGN" 05/01/1999 - "Here we describe clinical and morphological features in two siblings affected by MPGN and present complement and HLA typing studies done in patients and their parents" 11/01/1996 - "These results suggest that the glomerular leukocytes, infiltrating through Mac-1/complement interaction, express ICAM-3 by themselves, and that LFA-1/ICAM-3 interaction might participate in the glomerular aggregation of leukocytes in MPGN type I. In this study, we could not conclude that LFA-1/ICAM-1 or Mac-1/ICAM-1 interaction was involved in the leukocyte accumulation in this disease." 08/01/1982 - "Clinical study of complement breakdown products in patients with hypocomplementemic glomerulonephritis]" 11/01/1979 - "In MPGN with dense deposits, immunopathological studies indicate an activation of the complement system through the alternate pathway, NeF activity being present in 10 of 13 patients" Order ALL the reference details at left...
5.	InterferonsIBA 10/15/1995 - "Although interferon therapy has been effective in patients with both essential mixed cryoglobulinemia and membranoproliferative glomerulonephritis, a high relapse rate has been noted in the latter condition" 10/01/2006 - "Long term suppressive therapy with pegylated interferon for chronic hepatitis C associated membranoproliferative glomerulonephritis." 03/01/2000 - "Treatment of chronic viral hepatitis B in secondary membranoproliferative glomerulonephritis using recombinant alfa-2 interferon]" 01/05/1997 - "Interferon therapy in cryoglobulinemic membranoproliferative glomerulonephritis associated with hepatitis C]" 11/10/1996 - "Interferon therapy in cryoglobulinemic membranoproliferative glomerulonephritis associated with hepatitis C virus infection]" Order ALL the reference details at left...
6.	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/01/2008 - "Cyclosporine in the treatment of membranoproliferative glomerulonephritis." 07/01/2002 - "Cyclosporin A treatment for membranoproliferative glomerulonephritis type II." 02/01/1997 - "Recurrent type I membranoproliferative glomerulonephritis after renal transplantation and protective role of cyclosporine in acute crescentic transformation." 01/01/1997 - "Sandimmun was given for 2-18 months in a daily dose 3-5 mg/kg. Serum concentration 70-180 ng/ml. After 1 to 18 months of treatment nephrotic syndrome relieved in 1 MGN, 3 MPGN, 2 FSGS, 2 MCGS patients" 11/01/2001 - "Evaluation of cyclosporin A efficacy in the treatment of steroid-resistant nephrotic syndrome in the course of membranoproliferative glomerulonephritis--case report]" Order ALL the reference details at left...
7.	Adrenal Cortex Hormones (Corticosteroids)IBA 02/01/2006 - "These findings suggest that the indication of steroid therapy for atypical MPGN should be re-examined, since most of the patients with atypical MPGN seem to have an excellent prognosis without treatment with corticosteroids." 01/01/1989 - "A case of hypocomplementemic membranoproliferative glomerulonephritis was studied during remission of nephrosis induced by high doses of corticosteroids" 01/01/1986 - "Nine patients with mixed cryoglobulinemia and severe membranoproliferative glomerulonephritis were treated with plasma exchange alone or in combination with medium to low amounts of corticosteroids, but never with cytotoxic drugs" 02/01/2006 - "Atypical membranoproliferative glomerulonephritis (MPGN) has been reported to have a good prognosis when treated with corticosteroids" 03/01/2005 - "When vasculitis is active, corticosteroids are often required to permit healing of ulcers in the skin or to treat the membranoproliferative glomerulonephritis that is seen, thereby preventing loss of renal function" Order ALL the reference details at left...
8.	MethylprednisoloneFDA LinkGeneric 06/01/1995 - "The data support the evidence of other investigators that corticosteroid therapy is beneficial in type I MPGN and suggest that initiation with pulse methylprednisolone may promote early stabilization of the disease." 10/01/1995 - "Pulse methylprednisolone therapy in children with membranoproliferative glomerulonephritis." 06/01/1978 - "Evaluation of methylprednisolone pulse therapy in membranoproliferative glomerulonephritis]" 01/01/2008 - "We present a 41 year-old man with membranoproliferative glomerulonephritis in whom developed atrial fibrillation after oral methylprednisolone therapy." 01/01/2008 - "Atrial fibrillation due to oral methylprednisolone in a patient with membranoproliferative glomerulonephritis." Order ALL the reference details at left...
9.	Antigen-Antibody Complex (Immune Complex)IBA 04/01/1967 - "study indicates that the low serum levels of beta(1C)-globulin that may be present over long periods in patients with persistent hypocomplementemic glomerulonephritis can be ascribed, in part, to in vivo breakdown of this protein as a result of reaction with immune complexes" 02/01/2003 - "Pathogenesis of HCV-associated MPGN is mediated by glomerular deposition of circulating immune complexes containing HCV and anti-HCV" 01/01/2003 - "The pathogenesis of an immune complex-mediated membranoproliferative glomerulonephritis (IMPGN) involves persistent deposition of circulating immune complexes in the glomeruli caused by persistent antigenemia" 01/01/2003 - "Potential causes of antigenemia in the patients with an immune complex-mediated membranoproliferative glomerulonephritis in Lithuania]" 05/01/1997 - "These findings indicate that in MC patients with HCV-associated MPGN, kidney deposits consist of HCV-containing immune complexes that are likely to play a direct pathogenetic role in the renal damage." Order ALL the reference details at left...
10.	Complement C3 Nephritic FactorIBA 02/01/1990 - "She also had hypocomplementemia, mesangiocapillary glomerulonephritis type II, and a serum assay with positive results for C3 nephritic factor" 02/01/1997 - "The association of a C3 splitting activity, known as C3 nephritic factor (C3NeF), with mesangiocapillary glomerulonephritis (MCGN), especially MCGN type II, has long been known" 02/01/1997 - "C3 nephritic factor and mesangiocapillary glomerulonephritis." 07/20/1990 - "Detection of C3bBb-stabilizing activity (C3 nephritic factor) in the serum from patients with membranoproliferative glomerulonephritis." 01/01/1990 - "Similarly, membranoproliferative glomerulonephritis has been described in association with primary C3 deficiencies and the presence of C3 nephritic factor" Order ALL the reference details at left...

Therapies and Procedures

1.	Transplants (Transplant) 11/01/1996 - "Immunologic and virologic studies may help to differentiate hepatitis C virus-associated membranoproliferative glomerulonephritis from transplant glomerulopathy." 05/01/2007 - "METHODS: A survey was developed for this study that obtained information from the individual with MPGN or a guardian on: patient information, family/patient health history, history of PGN, medications, course of MPGN, history of dialysis, and history of transplant" 01/01/1976 - "Of the 12 patients with transplant tissue available for study, seven showed membranoproliferative glomerulonephritis by light morphology" 10/01/2008 - "Nephritic factor and recurrence in the renal transplant of membranoproliferative glomerulonephritis type II." 03/01/2008 - "Noncompliance and Type I MPGN play a role in producing this negative effect on graft outcome" Order ALL the reference details at left...
2.	Transplantation (Transplant Recipients) 02/01/2006 - "Severity of primary MPGN, rather than MPGN type, determines renal survival and post-transplantation recurrence risk." 01/01/1977 - "Three new cases with dense deposit disease affecting the original kidneys have been followed-up after transplantation for periods ranging from 4 to 8 years and illustrate the natural history of the recurrence" 01/01/1977 - "Dense deposit disease: long term follow-up of three cases of recurrence after transplantation." 05/01/1976 - "Transplantation in mesangiocapillary glomerulonephritis with intramembranous dense "deposits": recurrence of disease." 07/01/2005 - "Therefore, a retrospective comparative analysis of 75 patients with MPGN II contained in the North American Pediatric Renal Transplant Cooperative Study transplantation database was performed" Order ALL the reference details at left...
3.	Surgical Portasystemic Shunt (Portosystemic Shunt) 11/01/1997 - "Our study shows that MPGN type I may have developed secondary to portosystemic shunt" 11/01/2001 - "Full house' positive immunohistochemical membranoproliferative glomerulonephritis in a patient with portosystemic shunt." 03/01/2000 - "Membranoproliferative glomerulonephritis in congenital portosystemic shunt without liver cirrhosis." 11/01/1997 - "Membranoproliferative glomerulonephritis induced by portosystemic shunt surgery for non-cirrhotic portal hypertension." 11/01/1997 - "This secondary form of MPGN type I may be caused by a reduced clearance of immune complexes in the liver and their deposition in the glomerulus, since a portosystemic shunt routes portal venous blood from the intestinal tract directly to the systemic circulation." Order ALL the reference details at left...
4.	Plasmapheresis 01/01/2002 - "Management of membranoproliferative glomerulonephritis type II with plasmapheresis." 02/01/1988 - "Regression of recurrent membranoproliferative glomerulonephritis type II in a transplanted kidney after plasmapheresis therapy." 03/01/1984 - "Plasmapheresis and immunosuppression in dense deposit disease." 04/01/2000 - "Recurrent type I membranoproliferative glomerulonephritis in a renal allograft: successful treatment with plasmapheresis." 01/01/1995 - "Plasmapheresis maintained renal function in an allograft with recurrent membranoproliferative glomerulonephritis type I." Order ALL the reference details at left...
5.	Renal Dialysis (Hemodialysis) 04/01/1993 - "This case did not exhibit any clinical or serological abnormalities except for the renal disorder for a 10-year period after the histological diagnosis of MPGN, but was eventually diagnosed as SLE as a result of the manifestation of SLE symptoms for the first time after one year of maintenance hemodialysis" 11/01/2001 - "On the case of 35 old patient with steroid-resistant nephrotic syndrome in the course of membranoproliferative glomerulonephritis complicated with renal failure, we paid the attention to the therapeutic efficacy of CsA in this case with remission of nephrotic syndrome and significant improvement of renal function, which enabled us to withdraw the patient from the hemodialysis programme." 09/01/1982 - "We investigated the mechanism by which hypoxemia is produced in patients on dialysis by studying changes in neutrophil count, blood gases and pulmonary function in a patient with only trace amounts of circulating C3 associated with Type II mesangiocapillary glomerulonephritis and a control group of 6 patients with normal C3 levels during a 4 hour hemodialysis" 10/01/1985 - "We have studied complement activity, total leukocyte counts, PO2 and acid-base balance during a single hemodialysis with cuprophan membranes in a patient with hereditary angioedema and C3NeF-positive chronic membranoproliferative glomerulonephritis" Order ALL the reference details at left...