Significance of glycated LDL in different stages of diabetic nephropathy.

Abstract

AIM:

The aim of this study was to investigate the role of elevated glycated LDL (low-density lipoprotein) in the progression of diabetic kidney disease among type 2 diabetes (T2D) subjects.

MATERIALS AND METHODS:

This case-control observational study is a part of Saudi Diabetes Kidney Disease (SAUDI-DKD) study conducted during the period from April 2014 to June 2015. This study cohort is divided into two groups; the first group was T2D patients without diabetic nephropathy (DN) (n = 24) and the second group was T2D with DN (n = 45). Serum glycated LDL levels were determined by ELISA. Pearson's correlation analysis was performed, and the diagnostic accuracy was assessed using the area under the ROC curve.

RESULTS:

There was a threefold increase of serum glycated LDL level among diabetic subjects when compared with non-diabetic subjects and this level progressively increased with the progression of DN. The glycated LDL was found to have a significant diagnostic accuracy with AUC of 0.685 and 0.775 for cases with microalbuminuria and macroalbuminuria respectively.

CONCLUSION:

The glycated LDL could play a significant role in predicting diabetic patients who are susceptible to develop DN among T2D patients.

• Authors: Khalid Siddiqui, Teena P George, Shaik Sarfaraz Nawaz, Maram Yaslam, Ebtehal Almogbel, Khalid Al-Rubeaan
• Journal: Diabetes & metabolic syndrome (Diabetes Metab Syndr) 2019 Jan - Feb Vol. 13 Issue 1 Pg. 548-552 ISSN: 1878-0334 [Electronic] Netherlands
• PMID: 30641763 (Publication Type: Journal Article)
• Copyright: Copyright © 2018. Published by Elsevier Ltd.

Chemical References

• Biomarkers
• Glycation End Products, Advanced
• Lipoproteins, LDL
• glycated lipoproteins, LDL

Topics

• Adult
• Albuminuria (blood, diagnosis, epidemiology)
• Biomarkers (blood)
• Case-Control Studies
• Cohort Studies
• Diabetes Mellitus, Type 2 (blood, diagnosis, epidemiology)
• Diabetic Nephropathies (blood, diagnosis, epidemiology)
• Disease Progression
• Female
• Glycation End Products, Advanced
• Humans
• Lipoproteins, LDL (blood)
• Male
• Middle Aged
• Random Allocation
• Saudi Arabia (epidemiology)