RESULTS: Increase in AIP was associated with an increased risk for
hypertension (P < 0.05), HbA1c (P < 0.05), HOMA-IR (P < 0.05), UA (P < 0.05), and decreased eGFR levels (P < 0.05). Furthermore, AIP values directly correlated with BMI (r = 0.182, P < 0.001), waist circumference (r = 0.129, P < 0.001),
blood glucose index (FBG (r = 0.153, P < 0.001), PPBG (r = 0.117, P < 0.001), and HbA1c (r = 0.074, P < 0.001)),
insulin resistance (HOMA-IR; r = 0.112, P < 0.001), and
uric acid (UA, r = 0.177, P < 0.001). Multiple logistic regression analysis showed that waist circumference, HOMA-IR, FBG, systolic blood pressure, and UA were independent risk factors for AIP (all P < 0.05). The prevalence of
diabetic neuropathy and
metabolic syndrome was significantly higher among patients with higher AIP.
CONCLUSION: AIP represents a clinically convenient
indicator for the detection of T2DM with high risk of complications and associated diseases and thus is a good predictor and
indicator for follow-up monitoring in the treatment of patients with high-risk
type 2 diabetes.