Circulating Concentrations of Insulin Resistance-Associated Hepatokines, Selenoprotein P and Leukocyte Cell-Derived Chemotaxin 2, during an Oral Glucose Tolerance Test in Humans.

Abstract	A hepatokine is a collective term for liver-derived secretory factors whose previously-unrecognized functions have been recently elucidated. We have rediscovered selenoprotein P (SeP) and leukocyte cell-derived chemotaxin 2 (LECT2) as hepatokines that are involved in the development of insulin resistance and hyperglycemia. The aim of this study was to determine whether and, if so, how oral glucose loading alters the two hepatokines in humans. We measured concentrations of serum SeP and plasma LECT2 during 75 g oral glucose tolerance test (OGTT) (n = 20) in people with various degrees of glucose tolerance. In OGTT, concentrations of both serum SeP and plasma LECT2 decreased at 120 min compared with the baseline values, irrespective of the severity of glucose intolerance. Decrement of serum SeP during OGTT showed no correlations to the clinical parameters associated with insulin resistance or insulin secretion. In multiple stepwise regression analyses, plasma cortisol was selected as the variable to explain the changes in plasma concentrations of LECT2. The current data reveal the acute inhibitory actions of oral intake of glucose on circulating SeP and LECT2 in humans, irrespective of the severity of glucose intolerance. This study suggests that circulating SeP is regulated by the unknown clinical factors other than insulin and glucose during OGTT.
Authors	Kensuke Mohri, Hirofumi Misu, Hiroaki Takayama, Kiyo-Aki Ishii, Akihiro Kikuchi, Fei Lan, Yasufumi Enyama, Yumie Takeshita, Yoshiro Saito, Shuichi Kaneko, Toshinari Takamura
Journal	Biological & pharmaceutical bulletin (Biol Pharm Bull) Vol. 42 Issue 3 Pg. 373-378 (Mar 01 2019) ISSN: 1347-5215 [Electronic] Japan
PMID	30606895 (Publication Type: Journal Article)
Chemical References	Blood Glucose Insulin Intercellular Signaling Peptides and Proteins LECT2 protein, human Selenoprotein P Glucose
Topics	Aged Blood Glucose Diabetes Mellitus, Type 2 (blood) Female Glucose (administration & dosage) Glucose Intolerance Glucose Tolerance Test Humans Insulin (blood) Insulin Resistance (physiology) Intercellular Signaling Peptides and Proteins (blood) Male Middle Aged Selenoprotein P (blood)

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